École Polytechnique, Palaiseau, France.
Bull Math Biol. 2018 Jul;80(7):1689-1712. doi: 10.1007/s11538-018-0420-8. Epub 2018 Apr 2.
We study Eigen's quasispecies model in the asymptotic regime where the length of the genotypes goes to [Formula: see text] and the mutation probability goes to 0. A limiting infinite system of differential equations is obtained. We prove convergence of trajectories, as well as convergence of the equilibrium solutions. We give analogous results for a discrete-time version of Eigen's model, which coincides with a model proposed by Moran.
我们研究了 Eigen 的准种模型在渐进区域,其中基因型的长度趋于[公式:见正文],突变概率趋于 0。得到了一个极限无限微分方程组。我们证明了轨迹的收敛性以及平衡解的收敛性。我们给出了 Eigen 模型的离散时间版本的类似结果,它与 Moran 提出的模型一致。