Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lancet Oncol. 2018 Apr;19(4):e200-e208. doi: 10.1016/S1470-2045(18)30099-8.
The high cost of cancer care worldwide is largely attributable to rising drugs prices. Despite their high costs and potential toxic effects, anticancer treatments could be subject to overuse, which is defined as the provision of medical services that are more likely to harm than to benefit a patient. We found 30 studies documenting medication overuse in cancer, which included 16 examples of supportive medication overuse and 17 examples of antineoplastic medication overuse in oncology. Few specific agents have been assessed, and no studies investigated overuse of the most toxic or expensive medications currently used in cancer treatment. Although financial, psychological, or physical harms of medication overuse in cancer could be substantial, there is little published evidence addressing these harms, so their magnitude is unclear. Further research is needed to better quantify medication overuse, understand its implications, and help protect patients and the health-care system from overuse.
全球癌症治疗费用高昂，在很大程度上归因于药品价格不断上涨。尽管抗癌药物价格昂贵且可能具有毒性，但仍有可能被过度使用，过度使用是指提供的医疗服务弊大于利。我们发现有 30 项研究记录了癌症治疗中的药物过度使用，其中包括 16 个支持性药物过度使用的例子和 17 个抗肿瘤药物过度使用的例子。目前评估的特定药物种类很少，也没有研究调查目前在癌症治疗中使用的最有毒或最昂贵药物的过度使用情况。尽管癌症治疗中药物过度使用可能会造成重大的经济、心理或身体伤害，但有关这些伤害的证据很少，因此其严重程度尚不清楚。需要进一步研究来更好地量化药物过度使用，了解其影响，并帮助保护患者和医疗保健系统免受过度使用的影响。
