Arch Suicide Res. 2019 Jan-Mar;23(1):163-174. doi: 10.1080/13811118.2018.1450171. Epub 2018 Aug 27.
The aim of this study was to examine the link between suicidal ideation in adolescence (age 12-16) and symptoms of psychopathology in adulthood (age 22-26) in a birth cohort of extremely low birth weight (ELBW; <1000g) survivors and matched normal birth weight (NBW; >2500 g) control participants. This study utilized data from a longitudinally followed cohort of 129 ELBW survivors and 116 NBW individuals born in Ontario, Canada between the years 1977 and 1982. Participants self-reported suicidal ideation via questionnaire during adolescence (age 12-16). The depression, anxiety, inattention, and antisocial behavior subscales of the Young Adult Self Report (YASR) were used to assess symptoms of psychopathology during adulthood (age 22-26). Associations were examined in each birth weight group separately prior to and after adjustment for covariates. Before and after adjustment for covariates, suicidal ideation in NBW adolescents predicted symptoms of depression, anxiety, inattention, and antisociality in adulthood. Suicidal ideation among ELBW adolescents predicted inattentive and depressive symptoms, and antisocial behavior only before adjustment. Adolescents born at NBW who endorse suicidal ideation are at elevated risk for developing symptoms of anxiety, depression, inattention, and antisocial problems in adulthood even after adjustment. Among ELBW survivors, the risks were lower and appear to be due to confounding factors.
这项研究的目的是在极低出生体重（ELBW；<1000g）幸存者的队列和匹配的正常出生体重（NBW；>2500g）对照组中，研究青少年时期（12-16 岁）的自杀意念与成年时期（22-26 岁）精神病理学症状之间的关系。该研究利用了 1977 年至 1982 年间在加拿大安大略省出生的 129 名 ELBW 幸存者和 116 名 NBW 个体的纵向随访队列的数据。参与者在青少年时期（12-16 岁）通过问卷报告自杀意念。使用青少年自我报告（YASR）的抑郁、焦虑、注意力不集中和反社会行为子量表评估成年时期（22-26 岁）的精神病理学症状。在调整协变量之前和之后，分别在每个出生体重组中检查关联。在调整协变量之前和之后，NBW 青少年的自杀意念预测了成年后的抑郁、焦虑、注意力不集中和反社会症状。ELBW 青少年的自杀意念仅在调整前预测了注意力不集中和抑郁症状以及反社会行为。即使在调整后，有自杀意念的 NBW 出生的青少年也有更高的风险发展出焦虑、抑郁、注意力不集中和反社会问题的成年症状。在 ELBW 幸存者中，风险较低，这似乎是由于混杂因素造成的。
