Laboratory of Molecular Biology of Inflammation, IBMM, Faculty of Sciences, Université Libre de Bruxelles, Gosselies, Belgium; Laboratory of Experimental Medicine (ULB 222 Unit), CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
Laboratory of Experimental Medicine (ULB 222 Unit), CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
Arch Biochem Biophys. 2018 Jul 1;649:1-14. doi: 10.1016/j.abb.2018.03.037. Epub 2018 Mar 31.
Myeloperoxidase (MPO) is a member of the mammalian peroxidase family. It is mainly expressed in neutrophils, monocytes and macrophages. As a catalyzer of reactive oxidative species and radical species formation, it contributes to neutrophil bactericidal activity. Nevertheless MPO invalidation does not seem to have major health consequences in affected individuals. This suggests that MPO might have alternative functions supporting its conservation during evolution. We will review the available data supporting these non-canonical functions in terms of tissue specific expression, function and enzymatic activity. Thus, we discuss its cell type specific expression. We review in between others its roles in angiogenesis, endothelial (dys-) function, immune reaction, and inflammation. We summarize its pathological actions in clinical conditions such as cardiovascular disease and cancer.
髓过氧化物酶（MPO）是哺乳动物过氧化物酶家族的一员。它主要在中性粒细胞、单核细胞和巨噬细胞中表达。作为活性氧和自由基形成的催化剂，它有助于中性粒细胞的杀菌活性。然而，MPO 的失效似乎不会对受影响的个体的健康产生重大影响。这表明 MPO 可能具有支持其在进化过程中保守的替代功能。我们将根据组织特异性表达、功能和酶活性回顾支持这些非典型功能的现有数据。因此，我们讨论了它在细胞类型特异性表达中的作用。我们回顾了它在血管生成、内皮（功能障碍）功能、免疫反应和炎症中的作用。我们总结了它在心血管疾病和癌症等临床情况下的病理作用。
