Hogan D J, Strand L M, Lane P R
Department of Medicine, University of Saskatchewan, Saskatoon.
CMAJ. 1988 Jan 1;138(1):47-50.
The use of isotretinoin over a 2-year period was retrospectively studied in Saskatchewan. The database of the Saskatchewan Prescription Drug Plan was used to obtain the names of physicians who prescribed isotretinoin as well as the names of patients for whom it was prescribed. Of the 861 such patients 161 had been instructed to use the drug for at least 4 months by 42 physicians. Questionnaires were returned by 86 of the 161 patients and 22 of the 42 physicians. The responses confirmed that isotretinoin therapy is highly effective for acne. However, at least half of the patients for whom the agent was prescribed apparently did not complete a full 4- to 5-month course of treatment, and of the 34 women (average age 28 years) who responded to the questionnaire 12 (35%) did not use a method of contraception, which is a matter of concern in view of isotretinoin's teratogenic effects.
在萨斯喀彻温省对异维甲酸在两年期间的使用情况进行了回顾性研究。利用萨斯喀彻温省处方药计划的数据库获取了开具异维甲酸的医生姓名以及使用该药的患者姓名。在这861名此类患者中，161名患者由42名医生指导使用该药至少4个月。161名患者中的86名以及42名医生中的22名回复了问卷。回复证实异维甲酸疗法对痤疮非常有效。然而，至少一半开具该药的患者显然没有完成4至5个月的完整疗程，在回复问卷的34名女性（平均年龄28岁）中，有12名（35%）未采取避孕措施，鉴于异维甲酸的致畸作用，这是一个令人担忧的问题。
