Bionov Research, 34090 Montpellier, France.
EA7288 Université de Montpellier, 34093 Montpellier CEDEX 5, France.
Nutrients. 2018 Mar 31;10(4):437. doi: 10.3390/nu10040437.
Skin is the largest body organ and the first barrier to exogenous threats. This organ is constantly exposed to external factors such as ultraviolet radiation, which induces many adverse effects including sunburn, depigmentation, photo aging, photo immune suppression, and even skin cancer. Antioxidants seem to be good candidates in order to reduce ultraviolet-mediated damages and to prevent the health consequences of ultraviolet exposure. The present investigation aims to further characterize the potential skin photoprotective effects of a food supplementation and a topical administration of a melon concentrate alone or in combination. A clinical study assessing the Minimal Erythema Dose (MED) was first set up to evaluate photoprotection. Afterward, an independent in vitro study was performed on human skin explants from a donor to evaluate the effect of the melon concentrate at different levels including on the sunburn cells formation and on the endogenous antioxidant enzymes and its influence on melanin. Clinical study results demonstrate that melon concentrate application and/or supplementation increased MED. It also increased the endogenous antioxidant enzymes and reduced sunburn cells and melanin level on irradiated skin explants. Therefore, it is suggested that melon concentrate administration (oral and/or topical) could be a useful strategy for photoprotection due to its antioxidant properties.
皮肤是人体最大的器官，也是抵御外来威胁的第一道屏障。该器官不断受到紫外线等外界因素的影响，这些因素会导致许多不良影响，包括晒伤、脱色、光老化、光免疫抑制，甚至皮肤癌。抗氧化剂似乎是减少紫外线介导损伤和预防紫外线暴露带来的健康后果的一个很好的选择。本研究旨在进一步探讨单独或联合使用一种瓜浓缩物进行食物补充和局部给药的潜在皮肤光保护作用。首先建立了评估光保护作用的最小红斑剂量（MED）临床研究。随后，在来自供体的人体皮肤标本上进行了一项独立的体外研究，以评估瓜浓缩物在不同水平上的作用，包括对晒伤细胞形成以及内源性抗氧化酶的影响及其对黑色素的影响。临床研究结果表明，瓜浓缩物的应用和/或补充增加了 MED。它还增加了内源性抗氧化酶，减少了照射皮肤标本上的晒伤细胞和黑色素水平。因此，建议通过口服和/或局部给予瓜浓缩物（oral and/or topical）可能是一种有用的光保护策略，因为它具有抗氧化特性。
