a Colegiado de Ciências Farmacêuticas , Universidade Federal do Vale do São Francisco , Petrolina , Brazil.
b Laboratório de Química de Produtos Naturais e Sintéticos Bioativos , Universidade Estadual de Feira de Santana , Feira de Santana , Brazil.
Nat Prod Res. 2019 Sep;33(17):2571-2573. doi: 10.1080/14786419.2018.1457665. Epub 2018 Apr 4.
('alecrim-do-mato' or 'alecrim-do-campo') is used in Brazilian folk medicine to treat various illnesses, including diarrhea. This work aimed to evaluate spasmolytic and antidiarrheal activities of the essential oil (OOS) and to correlate with the traditional use of this plant. In isolated guinea-pig ileum, OOS presented a concentration-dependent spasmolytic activity in preparations pre-contracted with KCl 40 mM [EC = 16.89 (11.56-24.66) μg/mL], and antagonized phasic contractions induced by 1 μM carbachol [IC = 42.71 (37.35-48.83) μg/mL] or histamine [IC = 32.38 (27.44-38.20) μg/mL]. In mice, OOS at 400 mg/kg reduced intestinal transit, at 200 and 400 mg/kg reduced total stool mass and at 400 mg/kg reduced intestinal fluid accumulation. It was shown that the antidiarrheal effect of OOS is related to the inhibition of smooth muscle contraction and may be due to the presence of major compound β-caryophyllene in this essential oil.
（“alecrim-do-mato”或“alecrim-do-campo”）在巴西民间医学中被用于治疗各种疾病，包括腹泻。本工作旨在评估该植物精油的解痉和止泻活性，并与该植物的传统用途相关联。在分离的豚鼠回肠中，OOS 对用 40 mM KCl 预收缩的制剂表现出浓度依赖性的解痉活性[EC = 16.89（11.56-24.66）μg/mL]，并拮抗 1 μM 卡巴胆碱[IC = 42.71（37.35-48.83）μg/mL]或组胺[IC = 32.38（27.44-38.20）μg/mL]诱导的相位收缩。在小鼠中，OOS 以 400mg/kg 剂量降低肠道转运，以 200 和 400mg/kg 剂量减少总粪便质量，以 400mg/kg 剂量减少肠道液体积聚。结果表明，OOS 的止泻作用与抑制平滑肌收缩有关，这可能是由于该精油中存在主要化合物β-石竹烯。
