School of Public Health of Qingdao University, No. 38 Dengzhou Road, Qingdao, 266021, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao, 266033, China.
BMC Public Health. 2018 Apr 3;18(1):444. doi: 10.1186/s12889-018-5286-z.
To investigative the association of triglycerides (TG) and total cholesterol (TC) concentrations with impaired fasting glucose/ impaired glucose tolerance (IFG/IGT) in Chinese adults.
The population-based cross-sectional diabetes survey was conducted in 2006 and 2009 in Qingdao, separately. 4400 participants (1 793 men and 2607 women) were include in current analysis. IFG/IGT was defined according to fasting plasma glucose (FPG) and/or 2 h post-load plasma glucose (2 h PG). Logistic regression models and areas under receiver operating characteristic curves (AUROC) were performed to estimate the associations between TG, TC levels and IFG/IGT.
Spearman analysis showed that serum TG and TC was independently and positively associated with FPG and 2 h PG. As compared with normoglycaemia, the odds ratio[(95% confidence intervals), OR(95%CI)] for IFG/IGT corresponding to hypertriglyceridemia (HTG) were 1.61 (1. 17, 2. 22) in men and 1.57(1.15, 2.14) in women for TG and accompany with Hypercholesterolemia (HTC) 1.56 (1.15, 2.13) and 1. 20 (0.93, 1.54) for TC, when adjusting for confounding factor. The AUROCs of TG, TC for IFG/IGT were relatively smaller (0.50 < AUROC< 0. 7) in both gender. The optimal cut-offs for TG and TC was 1.61, 4.91 in men and 1. 24, 5. 32 in women, respectively.
Evaluated TG in both gender and TC in men were independently associated with the present of the IFG/IGT, yet, could not be an authentic predictors of IFG/IGT in both men and women in current Chinese population.
研究甘油三酯（TG）和总胆固醇（TC）浓度与中国成年人空腹血糖受损/糖耐量受损（IFG/IGT）的关系。
本研究为 2006 年和 2009 年在青岛进行的基于人群的横断面糖尿病调查。共纳入 4400 名参与者（男性 1793 名，女性 2607 名）进行当前分析。IFG/IGT 根据空腹血糖（FPG）和/或 2 小时餐后血糖（2 h PG）定义。采用 logistic 回归模型和受试者工作特征曲线下面积（AUROC）评估 TG、TC 水平与 IFG/IGT 的关系。
Spearman 分析显示，血清 TG 和 TC 与 FPG 和 2 h PG 独立呈正相关。与血糖正常相比，男性 TG 升高对应的 IFG/IGT 比值比（95%置信区间）为 1.61（1.172.22），女性为 1.57（1.152.14）；TC 升高对应的 IFG/IGT 比值比为 1.56（1.152.13）和 1.20（0.931.54），校正混杂因素后。在两性中，TG、TC 对 IFG/IGT 的 AUROC 相对较小（0.50< AUROC<0.7）。男性 TG 和 TC 的最佳截断值分别为 1.61 和 4.91，女性分别为 1.24 和 5.32。
在两性中，TG 与 TC 与 IFG/IGT 的发生独立相关，但在当前中国人群中，均不能作为 IFG/IGT 的真实预测因子。
