Sainsbury Laboratory, University of Cambridge, CB2 1LR Cambridge, United Kingdom.
Sainsbury Laboratory, University of Cambridge, CB2 1LR Cambridge, United Kingdom
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3846-E3855. doi: 10.1073/pnas.1717900115. Epub 2018 Apr 3.
The expansion of plants onto land was a formative event that brought forth profound changes to the earth's geochemistry and biota. Filamentous eukaryotic microbes developed the ability to colonize plant tissues early during the evolution of land plants, as demonstrated by intimate, symbiosis-like associations in >400 million-year-old fossils. However, the degree to which filamentous microbes establish pathogenic interactions with early divergent land plants is unclear. Here, we demonstrate that the broad host-range oomycete pathogen colonizes liverworts, the earliest divergent land plant lineage. We show that establishes a complex tissue-specific interaction with , where it completes a full infection cycle within air chambers of the dorsal photosynthetic layer. Remarkably, invaginates cells with haustoria-like structures that accumulate host cellular trafficking machinery and the membrane syntaxin MpSYP13B, but not the related MpSYP13A. Our results indicate that the intracellular accommodation of filamentous microbes is an ancient plant trait that is successfully exploited by pathogens like .
植物在陆地上的扩张是一个形成性事件，它给地球的地球化学和生物群带来了深远的变化。丝状真核微生物在陆地植物进化的早期就发展出了在植物组织中定殖的能力，这一点在超过 4 亿年前的化石中表现出了亲密的、类似共生的关系。然而，丝状微生物与早期分化的陆地植物建立致病性相互作用的程度尚不清楚。在这里，我们证明了广泛宿主范围的卵菌病原体 可以定殖苔类植物，这是最早分化的陆地植物谱系。我们表明 与 建立了一种复杂的组织特异性相互作用，其中它在背部光合层的空气室中完成了完整的感染周期。值得注意的是， 内陷具有类似吸器的结构的 细胞，这些结构积累了宿主细胞运输机制和膜联蛋白 MpSYP13B，但不是相关的 MpSYP13A。我们的结果表明，丝状微生物的细胞内容纳是一种古老的植物特性，像 这样的病原体成功地利用了这一特性。
