果蝇作为研究新陈代谢与癌症之间联系的模型。
Drosophila as a Model to Study the Link between Metabolism and Cancer.
作者信息
Herranz Héctor, Cohen Stephen M
机构信息
Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 N Copenhagen, Denmark.
出版信息
J Dev Biol. 2017 Dec 1;5(4):15. doi: 10.3390/jdb5040015.
Abstract
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
摘要
细胞代谢最近已被公认为癌症的一个标志。研究肿瘤细胞重编程代谢的起源和影响，并确定其遗传介质，将增进我们对这些变化如何促进疾病进展的理解，并可能提示新的治疗方法。正成为研究肿瘤形成和恶性转化多个方面的有价值模型。在本综述中，我们讨论使用作为模型来研究细胞代谢变化以及代谢疾病如何促成癌症。
相似文献
1
Drosophila as a Model to Study the Link between Metabolism and Cancer.果蝇作为研究新陈代谢与癌症之间联系的模型。
J Dev Biol. 2017 Dec 1;5(4):15. doi: 10.3390/jdb5040015.
2
as a toolkit to tackle cancer and its metabolism.作为一种应对癌症及其新陈代谢的工具。
Front Oncol. 2022 Aug 25;12:982751. doi: 10.3389/fonc.2022.982751. eCollection 2022.
3
Dysregulated metabolism contributes to oncogenesis.代谢失调促进肿瘤发生。
Semin Cancer Biol. 2015 Dec;35 Suppl:S129-S150. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8.
4
Lipid metabolism in Drosophila: development and disease.果蝇的脂质代谢：发育与疾病。
Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):44-50. doi: 10.1093/abbs/gms105.
5
What fuels the fly: Energy metabolism in and its application to the study of obesity and diabetes.果蝇的能量代谢：对肥胖和糖尿病的研究及其应用。
Sci Adv. 2021 Jun 9;7(24). doi: 10.1126/sciadv.abg4336. Print 2021 Jun.
6
Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster.饥饿选择的黑腹果蝇中与肥胖相关的心脏功能障碍。
Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R658-67. doi: 10.1152/ajpregu.00160.2015. Epub 2015 Jul 1.
7
Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms.肥胖和营养感应 TOR 通路在果蝇和脊椎动物中的作用：遗传机制的功能保守性。
Trends Endocrinol Metab. 2011 Feb;22(2):45-52. doi: 10.1016/j.tem.2010.11.002. Epub 2011 Jan 7.
8
Lipotoxicity and cardiac dysfunction in mammals and Drosophila.脂肪毒性与哺乳动物和果蝇的心脏功能障碍。
Crit Rev Biochem Mol Biol. 2011 Oct;46(5):376-85. doi: 10.3109/10409238.2011.599830. Epub 2011 Aug 19.
9
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation.一个用于分析果蝇代谢变化的遗传工具包为研究代谢对压力和恶性转化的反应提供了新的见解。
Sci Rep. 2019 Dec 27;9(1):19945. doi: 10.1038/s41598-019-56446-3.
10
Using Mouse and Models to Investigate the Mechanistic Links between Diet, Obesity, Type II Diabetes, and Cancer.利用小鼠模型研究饮食、肥胖、二型糖尿病和癌症之间的机制联系。
Int J Mol Sci. 2018 Dec 18;19(12):4110. doi: 10.3390/ijms19124110.
引用本文的文献
1
Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules.年龄和氧化应激诱导果蝇马氏管中心体扩增及肾结石形成。
Biol Open. 2024 Dec 15;13(12). doi: 10.1242/bio.061743. Epub 2024 Dec 16.
2
Sex-dimorphic tumor growth is regulated by tumor microenvironmental and systemic signals.性别二态性肿瘤生长受肿瘤微环境和全身信号调控。
Sci Adv. 2024 Dec 6;10(49):eads4229. doi: 10.1126/sciadv.ads4229.
3
Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia.dNKAP 功能受损导致果蝇上皮组织基因组不稳定和致瘤性生长。
J Mol Cell Biol. 2024 Apr 10;15(12). doi: 10.1093/jmcb/mjad078.
4
Yeast Hydrolysate Inhibits Lipid Accumulation via Regulation of Lipid Accumulation-Related Genes in a Model of High-Sugar Diet-Induced Obesity.酵母水解物通过调节高糖饮食诱导肥胖模型中与脂质积累相关的基因来抑制脂质积累。
Int J Mol Sci. 2023 Nov 14;24(22):16302. doi: 10.3390/ijms242216302.
5
Immunometabolic regulation during the presence of microorganisms and parasitoids in insects.昆虫体内微生物和寄生蜂存在时的免疫代谢调控。
Front Immunol. 2023 Sep 25;14:905467. doi: 10.3389/fimmu.2023.905467. eCollection 2023.
6
orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control.orsai 是果蝇的人类 ETFRF1 同源物，它将脂质分解代谢与生长控制联系起来。
BMC Biol. 2022 Oct 21;20(1):233. doi: 10.1186/s12915-022-01417-w.
7
diabetes models and its usage in the research of anti-diabetes management with traditional Chinese medicines.糖尿病模型及其在中药抗糖尿病治疗研究中的应用
Front Med (Lausanne). 2022 Aug 11;9:953490. doi: 10.3389/fmed.2022.953490. eCollection 2022.
8
Metabolic reprogramming in cancer: mechanistic insights from Drosophila.癌症中的代谢重编程：来自果蝇的机制见解。
Dis Model Mech. 2021 Jul 1;14(7):1-17. doi: 10.1242/dmm.048934. Epub 2021 Jul 9.
9
A new metabolic signature contributes to disease progression and predicts worse survival in melanoma.一种新的代谢特征有助于黑色素瘤的疾病进展，并预测更差的生存。
Bioengineered. 2020 Dec;11(1):1099-1111. doi: 10.1080/21655979.2020.1822714.
10
RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1.RhoBTB 蛋白通过拮抗 LKB1 的泛素化来调节 Hippo 通路。
G3 (Bethesda). 2020 Apr 9;10(4):1319-1325. doi: 10.1534/g3.120.401038.
本文引用的文献
1
Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity.人类癌细胞通过 MYC 活性来传递其竞争适应性。
Sci Rep. 2017 Oct 3;7(1):12568. doi: 10.1038/s41598-017-13002-1.
2
Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.肽硼酸逆转 Wnt 信号过度激活导致的脂肪细胞缺陷
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7469-E7478. doi: 10.1073/pnas.1621048114. Epub 2017 Aug 21.
3
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.线粒体丙酮酸代谢对肠道干细胞功能和增殖的调控
Nat Cell Biol. 2017 Sep;19(9):1027-1036. doi: 10.1038/ncb3593. Epub 2017 Aug 14.
4
Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.在与线粒体功能障碍相关的肥胖模型中，激活素信号传导介导肌肉与脂肪之间的通讯。
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8596-8601. doi: 10.1073/pnas.1708037114. Epub 2017 Jul 24.
5
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?重编程癌症中的葡萄糖代谢：能否将其用于癌症治疗？
Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.
6
In vivo genetic dissection of tumor growth and the Warburg effect.肿瘤生长与瓦伯格效应的体内遗传学剖析
Elife. 2016 Sep 1;5:e18126. doi: 10.7554/eLife.18126.
7
Body Fatness and Cancer--Viewpoint of the IARC Working Group.身体肥胖与癌症——国际癌症研究机构工作组的观点
N Engl J Med. 2016 Aug 25;375(8):794-8. doi: 10.1056/NEJMsr1606602.
8
High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression.高脂饮食诱导的转化生长因子-β/糖原合酶激酶信号通路通过TRIBbles表达引发胰岛素抵抗。
Sci Rep. 2016 Aug 3;6:30265. doi: 10.1038/srep30265.
9
Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer.适者生存：细胞竞争在发育、衰老和癌症中的重要作用。
Trends Cell Biol. 2016 Oct;26(10):776-788. doi: 10.1016/j.tcb.2016.05.009. Epub 2016 Jun 16.
10
Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.肥胖诱导的炎症和促结缔组织增生促进胰腺癌进展及化疗耐药。
Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. Epub 2016 May 31.
Zotero 插件