Herranz Héctor, Cohen Stephen M
Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 N Copenhagen, Denmark.
J Dev Biol. 2017 Dec 1;5(4):15. doi: 10.3390/jdb5040015.
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
细胞代谢最近已被公认为癌症的一个标志。研究肿瘤细胞重编程代谢的起源和影响，并确定其遗传介质，将增进我们对这些变化如何促进疾病进展的理解，并可能提示新的治疗方法。正成为研究肿瘤形成和恶性转化多个方面的有价值模型。在本综述中，我们讨论使用作为模型来研究细胞代谢变化以及代谢疾病如何促成癌症。
