Gul Evrim, Celik Kavak Ebru
Department of Emergency Medicine, Elazig Education and Research Hospital, Elazig, Turkey.
Department of Obstetrics and Gynecology, School of Medicine, Firat University, Elazig, Turkey.
J Pain Res. 2018 Mar 23;11:611-613. doi: 10.2147/JPR.S146603. eCollection 2018.
Primary dysmenorrhea (PD) is a common cause of pelvic pain that can cause limitations in daily activities. Treatment options sometimes result in failure, suggesting that different mechanisms may be effective in etiopathogenesis. Eosinophils are cells that are present in endometrium only in the perimenstrual period. The aim of this study was to evaluate the levels of eotaxin, a potent eosinophilic chemoattractant, in patients with PD.
Thirty patients with PD and thirty healthy women were included in the study. Venous blood sample of 10 mL was collected from each participant. Blood samples were taken in the first 2 days of the menstrual cycle at any period of the day. Serum eotaxin levels were determined by enzyme-linked immunofluorescence assay.
There were no statistically significant differences between the demographic properties of groups in terms of age and body mass index. Eotaxin levels were significantly different in patients with PD than the control subjects (=0.012).
Detection of different levels of eotaxin in patients with PD may be a new and important step in determining the factors contributing to the pathogenesis of dysmenorrhea.
原发性痛经（PD）是盆腔疼痛的常见原因，可导致日常活动受限。治疗方案有时会失败，这表明不同的机制可能在发病机制中起作用。嗜酸性粒细胞是仅在月经周期期间存在于子宫内膜中的细胞。本研究的目的是评估PD患者中一种强效嗜酸性粒细胞趋化因子——嗜酸性粒细胞趋化蛋白（eotaxin）的水平。
本研究纳入了30例PD患者和30名健康女性。从每位参与者采集10 mL静脉血样本。在月经周期的前2天的任何时间段采集血样。通过酶联免疫荧光测定法测定血清嗜酸性粒细胞趋化蛋白水平。
两组在年龄和体重指数方面的人口统计学特征无统计学显著差异。PD患者的嗜酸性粒细胞趋化蛋白水平与对照组相比有显著差异（P = 0.012）。
检测PD患者中不同水平的嗜酸性粒细胞趋化蛋白可能是确定导致痛经发病机制的因素的一个新的重要步骤。
