局部应用于大鼠大脑皮层的兴奋性氨基酸之间的相互作用：戊巴比妥的鉴别作用

Interactions between topically applied excitatory amino acids on rat cerebral cortex: discrimination by pentobarbitone.

作者信息

Addae J I, Stone T W

机构信息

Department of Physiology, St. George's Hospital Medical School, London, U.K.

出版信息

Exp Brain Res. 1987;68(3):613-8. doi: 10.1007/BF00249804.

DOI:10.1007/BF00249804

PMID:2961587

Abstract

The interaction between the effects of topically applied excitatory amino acid receptor agonists on the somatosensory evoked potentials (SEPs) were examined in urethane-anaesthetised rats. Preceding application of N-methyl-D, L-aspartic acid (NMDLA) prevented the effects of quinolinic acid or kainic acid but not those of carbachol or KCl. Similarly, quisqualic acid prevented the effects of NMDLA or kainic acid but not that of carbachol. Pentobartitone suppressed the inhibitory effect of quisqualic acid on NMDLA responses without altering the NMDLA response itself. It is concluded that an apparent desensitisation phenomenon occurs between the excitatory amino acids, distal to the receptor site.

摘要

在氨基甲酸乙酯麻醉的大鼠中，研究了局部应用兴奋性氨基酸受体激动剂对体感诱发电位（SEP）的影响之间的相互作用。在应用N-甲基-D，L-天冬氨酸（NMDLA）之前，可预防喹啉酸或 kainic 酸的作用，但不能预防卡巴胆碱或氯化钾的作用。同样，quisqualic 酸可预防NMDLA或 kainic 酸的作用，但不能预防卡巴胆碱的作用。戊巴比妥抑制了 quisqualic 酸对NMDLA反应的抑制作用，而不改变NMDLA反应本身。得出的结论是，在受体位点远端的兴奋性氨基酸之间出现了明显的脱敏现象。