使用磷脂酰胆碱非甾体抗炎药进行化学预防以及……（原文句子不完整）
Chemoprevention with phosphatidylcholine non-steroidal anti-inflammatory drugs and .
作者信息
Lichtenberger Lenard M, Phan Tri, Fang Dexing, Dial Elizabeth J
机构信息
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.
出版信息
Oncol Lett. 2018 May;15(5):6688-6694. doi: 10.3892/ol.2018.8098. Epub 2018 Feb 21.
The chemopreventive activity of non-steroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, has been well demonstrated in preclinical and clinical studies. However, the primary side effect from this class of drug is gastrointestinal (GI) bleeding, which has limited the widespread use of NSAIDs for the prevention of cancer. The development of GI-safer NSAIDs, which are associated with phosphatidylcholine (PC) may provide a solution to this therapeutic problem. In the present study, the efficacy of two NSAIDs, aspirin and indomethacin, were compared using murine colon cancer cell line MC-26. Each NSAID was assessed alone and in combination with PC, using and systems. The results reveal that the PC-associated NSAIDs had a significantly higher degree of protection against cancer cell growth compared with the unmodified NSAIDs. It was also observed that Aspirin-PC and Indomethacin-PC prevented the metastatic spread of cancer cells in a syngeneic mouse model. These results support the potential use of PC-NSAIDs for the chemoprevention of colorectal cancer.
非甾体抗炎药（NSAIDs），尤其是阿司匹林的化学预防活性已在临床前和临床研究中得到充分证明。然而，这类药物的主要副作用是胃肠道（GI）出血，这限制了NSAIDs在癌症预防中的广泛应用。与磷脂酰胆碱（PC）相关的胃肠道安全性更高的NSAIDs的开发可能为这一治疗问题提供解决方案。在本研究中，使用小鼠结肠癌细胞系MC-26比较了两种NSAIDs，阿司匹林和吲哚美辛的疗效。每种NSAIDs单独以及与PC联合使用，采用和系统进行评估。结果显示，与未修饰的NSAIDs相比，与PC相关的NSAIDs对癌细胞生长具有显著更高程度的保护作用。还观察到，阿司匹林-PC和吲哚美辛-PC在同基因小鼠模型中阻止了癌细胞的转移扩散。这些结果支持了PC-NSAIDs在结直肠癌化学预防中的潜在应用。
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