Deza Araujo Yacila I, Nebe Stephan, Neukam Philipp T, Pooseh Shakoor, Sebold Miriam, Garbusow Maria, Heinz Andreas, Smolka Michael N
Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Cogn Affect Behav Neurosci. 2018 Jun;18(3):536-549. doi: 10.3758/s13415-018-0586-4.
Value-based decision making (VBDM) is a principle that states that humans and other species adapt their behavior according to the dynamic subjective values of the chosen or unchosen options. The neural bases of this process have been extensively investigated using task-based fMRI and lesion studies. However, the growing field of resting-state functional connectivity (RSFC) may shed light on the organization and function of brain connections across different decision-making domains. With this aim, we used independent component analysis to study the brain network dynamics in a large cohort of young males (N = 145) and the relationship of these dynamics with VBDM. Participants completed a battery of behavioral tests that evaluated delay aversion, risk seeking for losses, risk aversion for gains, and loss aversion, followed by an RSFC scan session. We identified a set of large-scale brain networks and conducted our analysis only on the default mode network (DMN) and networks comprising cognitive control, appetitive-driven, and reward-processing regions. Higher risk seeking for losses was associated with increased connectivity between medial temporal regions, frontal regions, and the DMN. Higher risk seeking for losses was also associated with increased coupling between the left frontoparietal network and occipital cortices. These associations illustrate the participation of brain regions involved in prospective thinking, affective decision making, and visual processing in participants who are greater risk-seekers, and they demonstrate the sensitivity of RSFC to detect brain connectivity differences associated with distinct VBDM parameters.
基于价值的决策（VBDM）是一种原则，即人类和其他物种会根据所选或未选选项的动态主观价值来调整自己的行为。这一过程的神经基础已通过基于任务的功能磁共振成像（fMRI）和病变研究进行了广泛调查。然而，静息态功能连接（RSFC）这一不断发展的领域可能会为不同决策领域的大脑连接组织和功能提供线索。出于这个目的，我们使用独立成分分析来研究一大群年轻男性（N = 145）的大脑网络动态，以及这些动态与VBDM的关系。参与者完成了一系列行为测试，评估延迟厌恶、对损失的风险寻求、对收益的风险厌恶和损失厌恶，随后进行了RSFC扫描。我们识别出一组大规模脑网络，并仅对默认模式网络（DMN）以及包含认知控制、食欲驱动和奖励处理区域的网络进行分析。对损失更高的风险寻求与内侧颞叶区域、额叶区域和DMN之间连接性增加有关。对损失更高的风险寻求还与左额顶网络和枕叶皮质之间的耦合增加有关。这些关联说明了参与前瞻性思维、情感决策和视觉处理的脑区在风险寻求程度更高的参与者中的作用，并且它们证明了RSFC检测与不同VBDM参数相关的大脑连接差异的敏感性。
