a Clinic of Urology , Turkiye Yuksek Ihtisas Training and Research Hospital , Ankara , Turkey.
b Clinic of Nephrology , Turkiye Yuksek Ihtisas Training and Research Hospital , Ankara , Turkey.
Ren Fail. 2018 Nov;40(1):209-212. doi: 10.1080/0886022X.2018.1455590.
Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy.
We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient. Patients were divided into four groups: Group 1 (n = 46): Healthy controls; Group 2 (n = 50): Patients who had undergone unilateral partial nephrectomy; Group 3 (n = 46): Patients who had gone unilateral nephrectomy; Group 4 (n = 82): Patients who had CKD.
The mean NLR of each group was as follows: Group 1: 2.14 ± 0.73; Group 2: 3.52 ± 3.74; Group 3: 3.64 ± 3.52, and Group 4: 3.53 ± 2.30. NLR was lower in Group 1 compared to other groups but statistically significant difference was observed only between Group 1 (control) and Group 4 (CKD), 2.14 ± 0.73 versus 3.53 ± 2.30 (p = .005). In non-parametric correlation analysis NLR was found negatively correlated with GFR and positively correlated CKD stage (p = .028 for both correlations).
The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy.
慢性肾脏病（CKD）是全球范围内的一个主要健康问题，可导致终末期肾衰竭和心血管事件。中性粒细胞与淋巴细胞比值（NLR）是炎症的替代标志物，已在恶性肿瘤、高血压、心脏病和血管疾病中得到广泛研究。在本研究中，我们旨在研究 NLR 是否代表部分或根治性肾切除术后的肾脏储备和功能。
我们进行了一项回顾性研究，纳入在我院接受根治性/部分肾切除术的患者和/或因泌尿系统疾病就诊于泌尿科和肾病科的门诊患者。患者被分为四组：第 1 组（n=46）：健康对照组；第 2 组（n=50）：单侧部分肾切除术患者；第 3 组（n=46）：单侧肾切除术患者；第 4 组（n=82）：CKD 患者。
每组的平均 NLR 如下：第 1 组：2.14±0.73；第 2 组：3.52±3.74；第 3 组：3.64±3.52；第 4 组：3.53±2.30。第 1 组 NLR 低于其他组，但仅第 1 组（对照组）与第 4 组（CKD 组）之间存在统计学差异，2.14±0.73 与 3.53±2.30（p=0.005）。在非参数相关分析中，NLR 与 GFR 呈负相关，与 CKD 分期呈正相关（两者相关性 p=0.028）。
在接受部分或根治性肾切除术的患者中，NLR 可能是除 Cr 之外预测 CKD 的实用指标。
