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南亚人的癌症风险较低:简要报告。

Low Cancer Risk of South Asians: A Brief Report.

作者信息

Tran H Nicole, Udaltsova Natalia, Li Yan, Klatsky Arthur L

机构信息

Internist at the Oakland Medical Center in CA.

Data Consultant at the Division of Research in Oakland, CA.

出版信息

Perm J. 2018;22:17-095. doi: 10.7812/TPP/17-095.

DOI:10.7812/TPP/17-095
PMID:29616905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5882184/
Abstract

CONTEXT

South Asians (ancestry in India, Pakistan, Bangladesh, or Sri Lanka) may have lower cancer risk than other racial-ethnic groups.

OBJECTIVE

To supplement published cohort data suggesting low cancer risk in South Asians.

DESIGN

Logistic regression models with 7 covariates to study cancer mortality through 2012 in 273,843 persons (1117 South Asians) with baseline examination data from 1964 to 1985.

MAIN OUTCOME MEASURE

Cancer mortality.

RESULTS

Through 2012, death was attributed to cancer in 28,031 persons, of which 1555 were Asians, including 32 South Asians. The all-Asian vs white adjusted odds ratio was 1.0, and the South Asian vs white odds ratio was 0.5 (p < 0.001). In separate regressions, South Asians were at lower risk than blacks, Chinese, Filipinos, Japanese, or other Asians. The South Asian-white disparity was concentrated in men but was generally similar when strata of smoking, body mass index, baseline age, and date of death were compared.

CONCLUSION

These data support the observation that compared with whites and other Asian groups, South Asians, especially men, have a lower risk of cancer.

摘要

背景

南亚人(祖籍为印度、巴基斯坦、孟加拉国或斯里兰卡)患癌风险可能低于其他种族群体。

目的

补充已发表的队列研究数据,这些数据表明南亚人患癌风险较低。

设计

采用包含7个协变量的逻辑回归模型,对1964年至1985年有基线检查数据的273,843人(1117名南亚人)截至2012年的癌症死亡率进行研究。

主要观察指标

癌症死亡率。

结果

截至2012年,28,031人死于癌症,其中1555人为亚洲人,包括32名南亚人。全亚洲人与白人的校正比值比为1.0,南亚人与白人的比值比为0.5(p<0.001)。在单独的回归分析中,南亚人患癌风险低于黑人、中国人、菲律宾人、日本人或其他亚洲人。南亚人与白人的差异集中在男性中,但在比较吸烟、体重指数、基线年龄和死亡日期分层时,总体情况相似。

结论

这些数据支持以下观察结果:与白人和其他亚洲群体相比,南亚人,尤其是男性,患癌风险较低。

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本文引用的文献

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Body Mass Index and Mortality in a Very Large Cohort: Is It Really Healthier to Be Overweight?一个超大型队列中的体重指数与死亡率:超重真的更健康吗?
Perm J. 2017;21:16-142. doi: 10.7812/TPP/16-142.
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Risk of cancer in Asian Americans: a Kaiser Permanente cohort study.亚裔美国人患癌风险:一项凯撒医疗集团队列研究。
Cancer Causes Control. 2016 Oct;27(10):1197-207. doi: 10.1007/s10552-016-0798-2. Epub 2016 Aug 25.
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Br J Cancer. 2015 Jun 30;113(1):173-81. doi: 10.1038/bjc.2015.182. Epub 2015 Jun 16.
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Distribution of BRCA1 and BRCA2 Mutations in Asian Patients with Breast Cancer.亚洲乳腺癌患者中BRCA1和BRCA2基因突变的分布情况。
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