Gutiérrez-Delgado R I, Barraza-Villarreal A, Escamilla-Núñez C, Hernández-Cadena L, Garcia-Feregrino R, Shackleton C, Ramakrishnan U, Sly P D, Romieu I
a Instituto Nacional de Salud Pública (INSP) , Centro de Investigaciones en Salud Poblacional, Cuernavaca , Morelos , Mexico.
b Department of Children's Health and Environment , the University of Queensland , Brisbane , QLD , Australia.
J Asthma. 2019 Mar;56(3):296-302. doi: 10.1080/02770903.2018.1452934. Epub 2018 Apr 4.
Prenatal omega-3 fatty acids improve alveolarization, diminish inflammation, and improve pulmonary growth, but it is unclear whether these outcomes translate into improved postnatal lung function.
We assessed the effect of prenatal supplementation with docosahexaenoic acid (DHA) on offspring lung function through 60 months of age.
We included a cohort of 772 Mexican preschoolers whose mothers participated in a clinical trial (NCT00646360) of supplementation with DHA or a placebo from week 18-22 of gestation through delivery.
The children were followed after birth and anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. The effect of DHA was tested using a longitudinal mixed effect models.
Overall, mean (Standard Deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10 Hz during follow up period were 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and -5.2 (1.6), -4.8 (1.7), -4.6 (1.6), respectively. There were no significant differences in pulmonary function by treatment group. DHA did not affect the average lung function or the trajectories through 60 months.
Prenatal DHA supplementation did not influence pulmonary function in this cohort of Mexican preschoolers.
产前补充omega-3脂肪酸可改善肺泡化、减轻炎症并促进肺生长，但这些结果是否能转化为出生后肺功能的改善尚不清楚。
我们评估了产前补充二十二碳六烯酸（DHA）对60月龄后代肺功能的影响。
我们纳入了772名墨西哥学龄前儿童队列，其母亲参与了一项临床试验（NCT00646360），该试验从妊娠第18至22周直至分娩期间补充DHA或安慰剂。
对儿童出生后进行随访，并在36、48和60月龄时进行人体测量和强迫振荡测试。使用纵向混合效应模型测试DHA的效果。
总体而言，随访期间6、8和10Hz时呼吸系统阻力和呼吸系统电抗测量的平均值（标准差）分别为11.3（2.4）、11.1（2.4）、10.3（2.2）和-5.2（1.6）、-4.8（1.7）、-4.6（1.6）。治疗组之间肺功能无显著差异。DHA在60个月内未影响平均肺功能或其轨迹。
在这一墨西哥学龄前儿童队列中，产前补充DHA并未影响肺功能。
