State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
Fitoterapia. 2018 Jun;127:334-340. doi: 10.1016/j.fitote.2018.03.010. Epub 2018 Apr 1.
Four new carbazole alkaloid derivatives, including a pair of enantiomers of the heterodimers of carbazole and phenylpropanoid (1a/1b) and two rare polyprenylated carbazole alkaloids (2, 3), together with 19 known analogues (4-22), were isolated from the leaves and stems of Murraya microphylla. Their structures were established by UV, IR, 1D/2D NMR, and HRESIMS data analysis, and their absolute configurations were determined by comparison of experimental and calculated ECD data and the ECD exciton coupling method. All the isolates were evaluated for their cytotoxicities against HepG2, Du145, HCT-116, and HeLa tumor cell lines. Compounds 7 and 11 exhibited obvious cytotoxic effects on four cancer cell lines in a dose-dependent manner.
从芸香科九里香的叶和茎中分离得到了 4 个新的咔唑生物碱衍生物，包括一对咔唑和苯丙素的杂二聚体（1a/1b）的对映异构体和两个罕见的多聚异戊二烯基咔唑生物碱（2,3），以及 19 个已知类似物（4-22）。通过 UV、IR、1D/2D NMR 和 HRESIMS 数据分析确定了它们的结构，并通过比较实验和计算的 ECD 数据以及 ECD 激子耦合方法确定了它们的绝对构型。所有分离得到的化合物均对 HepG2、Du145、HCT-116 和 HeLa 肿瘤细胞系进行了细胞毒性评价。化合物 7 和 11 对四种癌细胞系表现出明显的剂量依赖性细胞毒性。
