Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia.
Central Laboratory, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia.
Molecules. 2023 Aug 5;28(15):5901. doi: 10.3390/molecules28155901.
is a plant genus within the Rutaceae family comprising over 17 species, which are widely distributed in Asia, Australia, and the Pacific Islands. Furthermore, these species have been used in traditional medicine to treat fever, pain, and dysentery. Several reports have also extensively studied the leaves, seeds, stembark, and bark of from 1965 to 2023 to explore their natural product composition. Various phytochemical studies have revealed the isolation of 413 compounds recorded, comprising coumarins, terpenoids, flavonoids, and aromatics, as well as alkaloids, which constitute the largest proportion (46.9%). These isolated compounds have long been known to exhibit different bioactivities, such as cytotoxic and anti-inflammatory properties. Cytotoxic activity has been observed against HCT 116, HeLa, HepG2, and other cell lines. Previous studies have also reported the presence of antifungal, hepatoprotective, antihyperlipidemic, antidiarrheal, and antioxidant effects. Therefore, this review provides a comprehensive overview of species, highlighting their phytochemistry, biological activities, and potential as a source of active natural compounds.
是芸香科的一个植物属，包含超过 17 个种，广泛分布于亚洲、澳大利亚和太平洋岛屿。此外，这些物种在传统医学中被用于治疗发热、疼痛和痢疾。自 1965 年至 2023 年，已有多项报道广泛研究了 的叶、种子、茎干和树皮，以探索其天然产物组成。各种植物化学研究揭示了已分离出 413 种化合物，包括香豆素、萜类、类黄酮和芳烃，以及生物碱，它们构成了最大的比例（46.9%）。这些分离出的化合物长期以来一直被认为具有不同的生物活性，如细胞毒性和抗炎特性。已观察到对 HCT 116、HeLa、HepG2 和其他细胞系的细胞毒性活性。先前的研究还报道了抗真菌、保肝、抗高血脂、抗腹泻和抗氧化作用。因此，本综述全面概述了 种的植物化学、生物活性及其作为活性天然化合物来源的潜力。
