大豆脂质输注对早产儿甘油三酯和非结合游离脂肪酸水平的影响。
Effects of soybean lipid infusion on triglyceride and unbound free fatty acid levels in preterm infants.
作者信息
Hegyi Thomas, Kleinfeld Alan, Huber Andrew, Weinberger Barry, Memon Naureen, Joe Shih Weichung, Carayannopoulos Mary, Oh William
机构信息
a Department of Pediatrics , Robert Wood Johnson Medical School, Rutgers, State University of New Jersey , New Brunswick , NJ , USA.
b Fluoresprobe Sciences , San Diego , CA , USA.
出版信息
J Matern Fetal Neonatal Med. 2019 Oct;32(19):3226-3231. doi: 10.1080/14767058.2018.1461827. Epub 2018 Apr 18.
To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybean lipid, intralipid (IL), infusion. TG and FFAu levels were measured in 78 preterm infants (BW 500-2000 g; GA 23-34 weeks) using the fluorescent probe ADIFAB2 and enzymatic method. The infants' BW was 1266.2 ± 440.7 g and GA 28.8 ± 3.1 weeks. TG levels were 77.4 ± 50 mg/dL, 140.2 ± 188 mg/dL ( < .04 compared to levels during low dose IL infusion) and 135.6 ± 118 mg/dL ( < .004), respectively during increased IL rates. FFAu levels were 17.7 ± 13 nM, 47.3 ± 102.8 nM ( = .07) and 98 ± 234 nM ( = .03). TG levels correlated with IL dose, the rate of IL administration, and FFAu levels. TG and FFAu levels were higher in infants below 28 weeks' gestation Increasing dosage of IL is associated with increasing levels of TG and FFAu, especially in infants below 29 weeks of gestation. The increased level of FFAu suggests inefficient cellular utilization.
为了确定接受递增剂量大豆脂质、英脱利匹特（IL）输注治疗的婴儿的血浆甘油三酯（TG）和非结合游离脂肪酸（FFAu）水平。使用荧光探针ADIFAB2和酶法对78例早产儿（出生体重500 - 2000 g；胎龄23 - 34周）的TG和FFAu水平进行了测量。婴儿的出生体重为1266.2±440.7 g，胎龄为28.8±3.1周。在递增IL速率期间，TG水平分别为77.4±50 mg/dL、140.2±188 mg/dL（与低剂量IL输注期间的水平相比，P<0.04）和135.6±118 mg/dL（P<0.004）。FFAu水平分别为17.7±13 nM、47.3±102.8 nM（P = 0.07）和98±234 nM（P = 0.03）。TG水平与IL剂量、IL给药速率和FFAu水平相关。胎龄低于28周的婴儿的TG和FFAu水平更高。IL剂量的增加与TG和FFAu水平的升高相关，尤其是在胎龄低于29周的婴儿中。FFAu水平的升高表明细胞利用效率低下。
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