血清中未结合游离脂肪酸水平。II：静脉输注脂肪乳剂对早产儿的影响。
Serum levels of unbound free fatty acids. II: The effect of intralipid administration in premature infants.
作者信息
Ruben S, Kleinfeld A M, Richeiri G V, Hiatt M, Hegyi T
机构信息
Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, St. Peter's Medical Center, New Brunswick 08903, USA.
出版信息
J Am Coll Nutr. 1997 Feb;16(1):85-7. doi: 10.1080/07315724.1997.10718654.
BACKGROUND
Fatty acids (FFA) are key nutrients in maintaining physiologic homeostasis and in the form of Intralipid administration, they are important sources of nutrition in the premature newborn infant. Complexed with albumin, fatty acids have a small but important fraction that remains unbound in the aqueous phase.
OBJECTIVE
The goal of this study was to examine the levels of serum levels of unbound free fatty acids (FFAu) in premature newborns following Intralipid administration.
METHOD
A fluorescent probe acrylodated intestinal fatty acid binding protein (ADIFAB) was used to measure (FFAu) before Intralipid and during increasing rates of infusion.
RESULTS
There were significant differences between (FFAu) values obtained before Intralipid and levels after the infusion of 1.0, 2.0, and 3.0 g/kg/day (p < 0.05). Regression analysis of Intralipid dose and FFAu yielded an r = 0.438 and the following relationship: [FFAu] = 26.39 + 3.60 * IL (g/kg/day).
CONCLUSIONS
Intralipid administration results in significant elevation of FFAu in the very low birth weight infant.
背景
脂肪酸（FFA）是维持生理稳态的关键营养素，以静脉输注脂肪乳剂（Intralipid）的形式，它们是早产新生儿重要的营养来源。与白蛋白结合的脂肪酸，有一小部分但很重要的部分在水相中保持未结合状态。
目的
本研究的目的是检测静脉输注脂肪乳剂后早产新生儿血清中未结合游离脂肪酸（FFAu）的水平。
方法
使用荧光探针丙烯酰化肠脂肪酸结合蛋白（ADIFAB）在输注脂肪乳剂前及输注速率增加时测量（FFAu）。
结果
输注脂肪乳剂前测得的（FFAu）值与输注1.0、2.0和3.0 g/kg/天之后的水平之间存在显著差异（p < 0.05）。脂肪乳剂剂量与FFAu的回归分析得出r = 0.438及以下关系：[FFAu] = 26.39 + 3.60 * IL（g/kg/天）。
结论
静脉输注脂肪乳剂会导致极低出生体重儿的FFAu显著升高。
Zotero 插件