Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Department of Cancer Epidemiology, Cancer Control Center, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Sci Rep. 2018 Apr 4;8(1):5612. doi: 10.1038/s41598-018-23947-6.
Japan's governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets of 20-year-old cervical cancer screening were females born in and before 1993, i.e., those who could not have received HPV vaccination because it was not yet publicly introduced. The targets during 2014-2019 are, or will be, those born in 1994-1999, i.e., those who came of age during a period with the highest HPV immunization rate. We analyzed the statistical data for each birth year, for the cumulative HPV vaccination rates achieved as of age 16, and for the corresponding results of cervical cancer screening at age 20. The rate of abnormal findings in cervical cytology increased slightly from 3.68% in 2010 (birth year: 1990) to 4.35% in 2013 (birth year: 1993); however, it dynamically dropped to 2.99% in 2014 (birth year: 1994) and 3.03% in 2015 (birth year: 1995). In total, the rate of abnormal findings in cervical cytology was 3.96% in 2010-2013, but significantly dropped to 3.01% in 2014-2015 (p = 0.014). This is the first description of dynamic changes occurring in the abnormal rate of cervical cancer screening as a result of positive changes in national HPV vaccination rates.
日本政府推荐 HPV 疫苗接种的措施已暂停超过 4 年。在 2013 年及以前，20 岁女性的宫颈癌筛查目标人群为 1993 年及以前出生的女性，因为她们在 HPV 疫苗尚未普及的时期无法接种疫苗。2014-2019 年的目标人群是 1994-1999 年出生的女性，也就是在 HPV 疫苗接种率最高的时期达到成年的人群。我们分析了每年的出生人数统计数据、截至 16 岁时 HPV 疫苗的累计接种率以及 20 岁时宫颈癌筛查的相应结果。宫颈细胞学异常的检出率从 2010 年（出生年份：1990 年）的 3.68%略有上升至 2013 年（出生年份：1993 年）的 4.35%；然而，它在 2014 年（出生年份：1994 年）动态下降至 2.99%，2015 年（出生年份：1995 年）进一步下降至 3.03%。2010-2013 年，宫颈细胞学异常检出率的总平均值为 3.96%，但在 2014-2015 年显著下降至 3.01%（p=0.014）。这是首次描述由于 HPV 疫苗接种率的积极变化导致宫颈癌筛查异常率的动态变化。
