Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Gynecology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
Cancer Sci. 2020 Jun;111(6):2156-2162. doi: 10.1111/cas.14406. Epub 2020 Apr 27.
In Japan, the serious adverse events after human papillomavirus (HPV) vaccination were widely reported in the media. The Ministry of Health, Labour and Welfare of Japan (MHLW) announced the suspension of the governmental recommendation of HPV vaccine in 2013, and the inoculation rate has since sharply declined. The estimated inoculation rate for each birth fiscal year (FY) announced by the MHLW and the actual numbers for each birth FY surveyed by local governments were very different. In particular, the cumulative vaccination rate of girls born in FY2000 was regarded to be as high as 42.9% by the Council of the MHLW. However, this estimation included a confusion. When the suspension of the governmental recommendation was announced in FY2013, the girls born in FY2000 turned 13 years old, the targeted starting age of the HPV vaccination. The vaccination rate of this generation is considered to be quite low. The numbers were recalculated in this study. This study revealed that the real vaccination rate is only 14.3%. Female individuals born in or after FY2000 have been confirmed to be exposed to the same cervical cancer risk as before the HPV vaccine was introduced in Japan.
在日本,人乳头瘤病毒(HPV)疫苗接种后的严重不良事件在媒体上被广泛报道。日本厚生劳动省(MHLW)于 2013 年宣布暂停 HPV 疫苗的政府推荐,此后接种率急剧下降。厚生劳动省公布的每个生育财政年度(FY)的估计接种率和地方政府调查的每个生育 FY 的实际数字差异很大。特别是,厚生劳动省理事会认为,2000 年出生的女孩的累计接种率高达 42.9%。然而,这一估计存在混淆。2013 年宣布暂停政府推荐时,2000 年出生的女孩年满 13 岁,这是 HPV 疫苗接种的目标起始年龄。这一代人的接种率被认为相当低。本研究对此进行了重新计算。研究表明,实际接种率仅为 14.3%。出生于或之后的 2000 年的女性个体被证实面临与日本引入 HPV 疫苗之前相同的宫颈癌风险。