Orhan Fatma Özlem, Kurutaş Ergül Belge, Doğaner Adem, Türker Ebru, Özcü Safiye Şeyma Taner, Güngör Meltem, Çakmak Seyfettin
Department of Psychiatry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey.
Department of Biochemistry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey.
Neuropsychiatr Dis Treat. 2018 Mar 26;14:855-862. doi: 10.2147/NDT.S158822. eCollection 2018.
Estrogen and its receptors have been suggested as playing a role in the pathogenesis of bipolar disorder (BD). Estrogen functions through the estrogen receptors alpha and beta and the recently discovered G-protein-coupled estrogen receptor-1 (GPER-1). The aim of this study was to evaluate serum GPER-1 levels in euthymic BD patients.
The study population consisted of 38 euthymic outpatients meeting the criteria for BD in the , Fifth Edition and 35 age- and gender-matched healthy controls. Medical histories were obtained and physical examinations and laboratory tests conducted.
Serum GPER-1 levels were measured in both patients and controls and found to be significantly higher in the BD patients than in controls. These results were not influenced by the medications in use.
The results of this study demonstrated that GPER-1 may play a role in BD pathophysiology.
雌激素及其受体被认为在双相情感障碍（BD）的发病机制中起作用。雌激素通过雌激素受体α和β以及最近发现的G蛋白偶联雌激素受体1（GPER-1）发挥作用。本研究的目的是评估双相情感障碍缓解期患者血清GPER-1水平。
研究人群包括38名符合《精神疾病诊断与统计手册》第五版双相情感障碍标准的缓解期门诊患者和35名年龄及性别匹配的健康对照者。获取了病史并进行了体格检查和实验室检查。
对患者和对照者均检测了血清GPER-1水平，发现双相情感障碍患者的血清GPER-1水平显著高于对照者。这些结果不受正在使用的药物影响。
本研究结果表明，GPER-1可能在双相情感障碍的病理生理学中起作用。
