Sandtorv Lisbeth Beate, Fevang Silje Katrine Elgen, Nilsen Sondre Aasen, Bøe Tormod, Gjestad Rolf, Haugland Siren, Elgen Irene Bircow
Department of Child and Adolescent Psychiatry, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Subst Abuse. 2018 Mar 22;12:1178221818765773. doi: 10.1177/1178221818765773. eCollection 2018.
Prenatal exposure to substances may influence a child's neurodevelopment and impact on subsequent mental health. In a hospital-based population of school-aged children prenatally exposed to opiates and a number of illicit substances (n = 57), we evaluated mental health symptoms associated with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) using the Swanson, Nolan, and Pelham Questionnaire, revision IV (SNAP-IV) and the Autism Spectrum Screening Questionnaire (ASSQ) and compared the scores to a reference group which comprised children from the population-based Bergen Child Study (n = 171). Prenatally exposed children had significantly higher SNAP-IV scores associated with ADHD symptoms in both areas of inattention and hyperactivity/impulsivity and also reported a higher ASSQ score related to an increased number of symptoms associated with ASD, compared with the reference group. Of tested predictors of mental health outcomes in the exposed group, the intelligence quotient was a strong predictor of most mental health outcomes, and neonatal abstinence syndrome was a predictor of inattention. In conclusion, prenatally exposed children had more mental health symptoms associated with ADHD and ASD, compared with the reference group.
产前接触某些物质可能会影响儿童的神经发育，并对其后续心理健康产生影响。在一个以医院为基础的学龄儿童群体中，这些儿童在产前接触过阿片类药物和多种非法物质（n = 57），我们使用斯旺森、诺兰和佩勒姆问卷第四版（SNAP-IV）以及自闭症谱系筛查问卷（ASSQ）评估了与注意力缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）相关的心理健康症状，并将分数与一个参考组进行比较，该参考组由基于人群的卑尔根儿童研究中的儿童组成（n = 171）。与参考组相比，产前接触过物质的儿童在注意力不集中和多动/冲动这两个方面与ADHD症状相关的SNAP-IV分数显著更高，并且报告的ASSQ分数也更高，这与与ASD相关的症状数量增加有关。在暴露组中测试的心理健康结果预测因素中，智商是大多数心理健康结果的强有力预测因素，而新生儿戒断综合征是注意力不集中的一个预测因素。总之，与参考组相比，产前接触过物质的儿童有更多与ADHD和ASD相关的心理健康症状。
