微生物群、炎症与结直肠癌
Microbiota, Inflammation and Colorectal Cancer.
作者信息
Lucas Cécily, Barnich Nicolas, Nguyen Hang Thi Thu
机构信息
M2iSH, UMR 1071 Inserm, University of Clermont Auvergne, INRA USC 2018, Clermont-Ferrand 63001, France.
出版信息
Int J Mol Sci. 2017 Jun 20;18(6):1310. doi: 10.3390/ijms18061310.
Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment.
结直肠癌是全球癌症相关死亡的第四大主要原因，是一种涉及遗传、环境和生活方式等风险因素的多因素疾病。此外，越来越多的证据表明肠道微生物群在结直肠癌的发生发展中起作用。事实上，已有报道称与对照受试者相比，结直肠癌患者的肠道微生物群组成发生了变化。几种细菌已被证明具有促炎和促癌特性，这可能会对结直肠癌的发生产生影响。本综述将总结目前关于肠道微生物群与结直肠癌之间潜在联系的知识，重点关注细菌微生物群的促癌特性，如炎症诱导、干扰细胞周期调控的基因毒素生物合成以及有毒代谢产物的产生。最后，我们将描述基于肠道微生物群调控的结直肠癌治疗潜在策略。
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