Komaki Shohei, Shiwa Yuh, Furukawa Ryohei, Hachiya Tsuyoshi, Ohmomo Hideki, Otomo Ryo, Satoh Mamoru, Hitomi Jiro, Sobue Kenji, Sasaki Makoto, Shimizu Atsushi
Division of Biomedical Information Analysis, Iwate Medical University, Shiwa, Iwate, Japan.
Division of Biobank and Data Management, Iwate Medical University, Shiwa, Iwate, Japan.
Hum Genome Var. 2018 Mar 29;5:18008. doi: 10.1038/hgv.2018.8. eCollection 2018.
We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (24 million autosomal CpG sites), whole-genome (9 million single-nucleotide variants), and whole-transcriptome (>14 000 genes) data for CD4 T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. These data were obtained from whole-genome bisulfite sequencing, whole-genome sequencing, and whole-transcriptome sequencing, making iMETHYL a comprehensive database.
我们推出了一个整合多组学数据库iMETHYL（http://imethyl.iwate-megabank.org）。iMETHYL提供了从约100名受试者收集的CD4 T淋巴细胞、单核细胞和中性粒细胞的全DNA甲基化数据（约2400万个常染色体CpG位点）、全基因组数据（约900万个单核苷酸变异）和全转录组数据（>14000个基因）。这些数据通过全基因组亚硫酸氢盐测序、全基因组测序和全转录组测序获得，使iMETHYL成为一个综合性数据库。
