Burke Mary V, Small Dana M
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, U.S.
John B. Pierce Laboratory, 290 Congress Avenue, New Haven, CT, U.S.
Curr Opin Behav Sci. 2016 Jun;9:97-105. doi: 10.1016/j.cobeha.2016.02.036. Epub 2016 Mar 9.
Emerging evidence from human and animal studies suggest that consumption of palatable foods rich in fat and/or carbohydrates may produce deleterious influences on brain function independently of body weight or metabolic disease. Here we consider two mechanisms by which diet can impact striatal circuits to amplify food cue reactivity and impair inhibitory control. First, we review findings demonstrating that the energetic properties of foods regulate nucleus accumbens food cue reactivity, a demonstrated predictor of weight gain susceptibility, which is then sensitized by chronic consumption of an energy dense diet. Second, we consider evidence for diet-induced adaptations in dorsal striatal dopamine signaling that is associated with impaired inhibitory control and negative outcome learning.
来自人类和动物研究的新证据表明，食用富含脂肪和/或碳水化合物的美味食物可能会对大脑功能产生有害影响，而与体重或代谢疾病无关。在这里，我们考虑饮食影响纹状体回路以增强食物线索反应性并损害抑制控制的两种机制。首先，我们回顾了一些研究结果，这些结果表明食物的能量特性调节伏隔核食物线索反应性，这是体重增加易感性的一个已证实的预测指标，长期食用能量密集型饮食会使其变得敏感。其次，我们考虑饮食诱导背侧纹状体多巴胺信号适应性变化的证据，这与抑制控制受损和负面结果学习有关。
