Simon Joe J, Wetzel Anne, Sinno Maria Hamze, Skunde Mandy, Bendszus Martin, Preissl Hubert, Enck Paul, Herzog Wolfgang, Friederich Hans-Christoph
Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
JCI Insight. 2017 Aug 3;2(15). doi: 10.1172/jci.insight.92970.
Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks.
Twenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward. Every participant was scanned twice in a counterbalanced fashion, both during a fasted state (after 24 hours fasting) and satiety. A functional connectivity analysis was performed to investigate the influence of satiety signaling on activation in neural reward networks. Blood samples were collected to assess hormonal satiety signaling.
Fasting was associated with sensitization of the striatal reward system to the anticipation of food reward irrespective of reward magnitude. Furthermore, during satiety, individual ghrelin levels were associated with increased neural processing during the expectation of food-related reward.
Our findings show that physiological hunger stimulates food consumption by specifically increasing neural processing during the expectation (i.e., incentive salience) but not the receipt of food-related reward. In addition, these findings suggest that ghrelin signaling influences hedonic-driven food intake by increasing neural reactivity during the expectation of food-related reward. These results provide insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward.
ClinicalTrials.gov NCT03081585.
This work was supported by the German Competence Network on Obesity, which is funded by the German Federal Ministry of Education and Research (FKZ 01GI1122E).
食物摄入受体内稳态需求和食物奖励价值的引导，但两者之间的确切关系仍不清楚。本研究的目的是调查不同代谢状态和激素饱腹感信号对神经奖励网络反应的影响。
23名健康参与者在执行区分预期和接收食物或金钱相关奖励的任务时接受功能磁共振成像扫描。每位参与者以平衡的方式在禁食状态（禁食24小时后）和饱腹状态下各扫描两次。进行功能连接分析以研究饱腹感信号对神经奖励网络激活的影响。采集血样以评估激素饱腹感信号。
禁食与纹状体奖励系统对食物奖励预期的敏感性增加有关，而与奖励大小无关。此外，在饱腹状态下，个体胃饥饿素水平与预期食物相关奖励期间神经处理增加有关。
我们的研究结果表明，生理饥饿通过在预期（即动机显著性）而非接收食物相关奖励期间特异性增加神经处理来刺激食物消费。此外，这些结果表明，胃饥饿素信号通过在预期食物相关奖励期间增加神经反应性来影响享乐驱动的食物摄入。这些结果为食物奖励的动机处理和享乐评估的神经生物学基础提供了见解。
ClinicalTrials.gov NCT03081585。
这项工作得到了德国肥胖症能力网络的支持，该网络由德国联邦教育与研究部资助（FKZ 01GI1122E）。
