Mazzocchi G, Rebuffat P, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
J Steroid Biochem. 1987 Dec;28(6):643-6. doi: 10.1016/0022-4731(87)90392-x.
A prolonged infusion with ANF induced atrophy of zona glomerulosa cells of rat adrenals and lowering of plasma concentration of aldosterone, without provoking significant changes in PRA. It also notably reduced the rise in the aldosterone plasma level caused by the acute stimulation with angiotensin II. Zona fasciculata cells and the blood concentration of corticosterone did not display any significant change. These findings are interpreted to indicate that ANF exerts an inhibitory effect on the growth and secretory activity of rat zona glomerulosa.
心房钠尿肽（ANF）的长时间输注导致大鼠肾上腺球状带细胞萎缩以及血浆醛固酮浓度降低，而肾素活性（PRA）无显著变化。它还显著降低了血管紧张素II急性刺激所引起的血浆醛固酮水平升高。束状带细胞和皮质酮的血浓度未显示任何显著变化。这些发现被解释为表明ANF对大鼠球状带的生长和分泌活性具有抑制作用。
