生长抑素对大鼠肾上腺球状带生长及类固醇生成能力的抑制作用。
Inhibitory effect of somatostatin on the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
作者信息
Rebuffat P, Robba C, Mazzocchi G, Nussdorfer G G
出版信息
J Steroid Biochem. 1984 Oct;21(4):387-90. doi: 10.1016/0022-4731(84)90301-7.
PMID:6149334
Abstract
Chronic administration of somatostatin induced atrophy of zona glomerulosa cells of rat adrenals and lowering of plasma aldosterone concentration. Zona fasciculata cells did not display any significant change and corticosterone plasma concentration was not significantly affected. These findings are interpreted to indicate that somatostatin exerts a direct inhibitory effect on the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
摘要
长期给予生长抑素可导致大鼠肾上腺球状带细胞萎缩，并降低血浆醛固酮浓度。束状带细胞未出现任何显著变化，血浆皮质酮浓度也未受到显著影响。这些研究结果被解释为表明生长抑素对大鼠肾上腺球状带的生长和类固醇生成能力具有直接抑制作用。
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