Becker K-F, Wipperfürth J, Herpel E
Gewebebank des Klinikums rechts der Isar und der Fakultät für Medizin der TU München, Technische Universität München, München, Deutschland.
Zentralisierte Biomaterialbank der medizinischen Fakultät der RWTH Aachen Universität, Aachen, Deutschland.
Pathologe. 2018 Jul;39(4):297-302. doi: 10.1007/s00292-018-0437-7.
Access to well-characterized human biosamples is one of the most important prerequisites for modern biomedical research. Biobanks play a decisive role here, as they provide corresponding biosamples for planned analyses. Many interfering factors influencing the quality of biosamples have to be taken into account. In addition to logistical, ethical, and data protection aspects, preanalytical variables in the context of sample acquisition, storage, and processing should be mentioned in particular. In this paper, therefore, the most important preanalytical influencing factors are presented systematically and an overview of current national and international activities for the standardized recording of these factors is provided with the goal of being able to better understand their influence on results and to minimize them in the near future.
获取特征明确的人类生物样本是现代生物医学研究最重要的前提条件之一。生物样本库在此起着决定性作用，因为它们为计划中的分析提供相应的生物样本。必须考虑许多影响生物样本质量的干扰因素。除了后勤、伦理和数据保护方面，尤其应提及样本采集、储存和处理过程中的分析前变量。因此，本文系统地介绍了最重要的分析前影响因素，并概述了当前国内和国际为标准化记录这些因素而开展的活动，目的是能够更好地理解它们对结果的影响，并在不久的将来将其降至最低。
