Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, 41 Victoria Pde, Fitzroy, 3065, VIC, Australia.
Endocrine Centre of Excellence, Austin Health, Heidelberg, Australia.
Osteoporos Int. 2018 Jul;29(7):1671-1674. doi: 10.1007/s00198-018-4498-5. Epub 2018 Apr 4.
Two women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29 years old with a BMD T-score of - 3.2 SD at the spine and- 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of - 4.5 SD at the spine and - 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investigation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocytosis. Lactation causes bone loss, but the occurrence of fractures in the setting of severe deficits in BMD and microstructural deterioration signals the need to consider additional causes of bone loss.
两名哺乳期女性出现脆性骨折，其骨密度（BMD）降低程度大于通常与哺乳期相关的程度。第一位女性 29 岁，其脊柱 BMD T 评分-3.2 SD，股骨颈 BMD T 评分-2.0 SD。第二位女性 35 岁，其脊柱 BMD T 评分-4.5 SD，股骨颈 BMD T 评分-2.8 SD。两名女性均出现皮质多孔性增加和小梁密度降低。检查发现血清胰蛋白酶升高，骨髓活检证实了肥大细胞增多症的诊断。哺乳期会导致骨质流失，但在 BMD 严重不足和微观结构恶化的情况下发生骨折，表明需要考虑其他导致骨质流失的原因。
