Sarier Mehmet, Sepin Ozen Nevgun, Guler Hicran, Duman Ibrahim, Yüksel Yücel, Tekin Sabri, Yavuz Asuman Havva, Yucetin Levent, Erdogan Yilmaz Mine
From the Department of Urology, Altinbas University, Istanbul, Turkey.
Exp Clin Transplant. 2018 Apr 4. doi: 10.6002/ect.2017.0232.
Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays.
This prospective controlled study was conducted between November 2016 and January 2017 in our hospital. Our study group included 80 consecutive, sexually active asymptomatic patients (40 men and 40 women) who had undergone renal transplant in our hospital and who presented to our outpatient clinic for routine follow-up. We also included a control group of 80 consecutive, sexually active nontransplant patients (40 men and 40 women). All patient samples were tested for Gardnerella vaginalis and obligate anaerobes (Prevotella bivia, Porphyromonas species), Candida species, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma species, Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, and Cytomegalovirus by real-time multiplex polymerase chain reaction.
The prevalences of infection with Gardnerella vaginalis and obligate anaerobes (P = .043), Ureaplasma species (P = .02), and Cytomegalovirus (P = .016) were found to be significantly higher in the study group versus the control group. However, there was no difference between the 2 groups regarding the prevalence of Mycoplasma infection (P = .70).
Sexually transmitted diseases may occur more frequently in sexually active asymptomatic renal transplant recipients than in nontransplanted individuals. Real-time multiplex polymerase chain reaction analysis may be a suitable method for determining these pathogens.
性传播疾病可能无症状，但有在肾移植受者中引发严重健康问题的潜在风险。本研究旨在通过实时多重聚合酶链反应检测法确定性活跃的无症状肾移植患者中性传播疾病的患病率。
本前瞻性对照研究于2016年11月至2017年1月在我院进行。研究组包括80例连续的、性活跃的无症状患者（40名男性和40名女性），他们在我院接受了肾移植，并到门诊进行常规随访。我们还纳入了80例连续的、性活跃的非移植患者作为对照组（40名男性和40名女性）。所有患者样本均通过实时多重聚合酶链反应检测阴道加德纳菌和专性厌氧菌（二路普雷沃菌、卟啉单胞菌属）、念珠菌属、人型支原体、生殖支原体、脲原体属、阴道毛滴虫、淋病奈瑟菌、沙眼衣原体、单纯疱疹病毒1型和2型以及巨细胞病毒。
研究组中阴道加德纳菌和专性厌氧菌感染率（P = 0.043）、脲原体属感染率（P = 0.02）和巨细胞病毒感染率（P = 0.016）显著高于对照组。然而，两组间支原体感染率无差异（P = 0.70）。
性活跃的无症状肾移植受者中性传播疾病的发生率可能高于未移植个体。实时多重聚合酶链反应分析可能是确定这些病原体的合适方法。
