Chien Y H, Iwashima M, Wettstein D A, Kaplan K B, Elliott J F, Born W, Davis M M
Department of Medical Microbiology, Stanford University School of Medicine, California 94305-5402.
Nature. 1987;330(6150):722-7. doi: 10.1038/330722a0.
The T-cell receptor delta-chain variable region can be assembled from as many as four distinct gene segments, V, D1, D2 and J, more than any other antigen-receptor gene. In fetal thymocytes V----D joinings are as common as D----J or VDJ rearrangements and one V gene segment predominates. Analysis of rearrangements at TCR gamma and delta loci during fetal ontogeny suggests abrupt changes and possible coordinate control in the rearrangement and expression of these loci.
T细胞受体δ链可变区可由多达四个不同的基因片段V、D1、D2和J组装而成，这比任何其他抗原受体基因都多。在胎儿胸腺细胞中，V-D连接与D-J或VDJ重排一样常见，且一个V基因片段占主导地位。对胎儿发育过程中TCRγ和δ基因座重排的分析表明，这些基因座的重排和表达存在突然变化以及可能的协同控制。
