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LTBP2 促进胃癌细胞的迁移和侵袭，并预测胃癌患者的不良预后。

LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer.

机构信息

Fourth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Department of Ultrasound, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.

出版信息

Int J Oncol. 2018 Jun;52(6):1886-1898. doi: 10.3892/ijo.2018.4356. Epub 2018 Apr 4.

DOI:10.3892/ijo.2018.4356
PMID:29620158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5919710/
Abstract

Latent transforming growth factor-β-binding protein (LTBP)2 is a member of the fibrillin/LTBP superfamily of extracellular matrix proteins, and has been demonstrated to exhibit tumor-promoting and tumor-suppressive functions in different types of cancer. However, the function of LTBP2 in gastric cancer (GC) remains unknown. The aim of the present study was to investigate the expression and molecular function of LTBP2 in GC, and to evaluate its prognostic value for patients with GC. The results revealed that the expression of LTBP2 was upregulated in GC tissues and cell lines. Increased LTBP2 expression was associated with poor overall survival in patients with early-stage [tumor-node-metastasis (TNM) I/II] and late-stage (TNM III/IV) GC. Furthermore, silencing of LTBP2 effectively suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition in GC cells. These results suggested that LTBP2 may be considered as a potential therapeutic target and a promising prognostic biomarker for human GC.

摘要

潜伏转化生长因子-β结合蛋白 (LTBP)2 是细胞外基质蛋白纤连蛋白/LTBP 超家族的成员，已被证明在不同类型的癌症中具有促进肿瘤和抑制肿瘤的功能。然而，LTBP2 在胃癌（GC）中的作用尚不清楚。本研究旨在探讨 LTBP2 在 GC 中的表达和分子功能，并评估其对 GC 患者的预后价值。结果显示，LTBP2 在 GC 组织和细胞系中表达上调。LTBP2 表达增加与早期（肿瘤-淋巴结-转移（TNM）I/II 期）和晚期（TNM III/IV 期）GC 患者的总生存期不良相关。此外，沉默 LTBP2 可有效抑制 GC 细胞的增殖、迁移、侵袭和上皮-间充质转化。这些结果表明，LTBP2 可能被认为是人类 GC 的潜在治疗靶点和有前途的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/12bab15e4307/IJO-52-06-1886-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/3d989db8c342/IJO-52-06-1886-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/8171aaa3a6d0/IJO-52-06-1886-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/7f36f8de3d68/IJO-52-06-1886-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/c8a00d5c8cba/IJO-52-06-1886-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/bf407ea6935f/IJO-52-06-1886-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/12bab15e4307/IJO-52-06-1886-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/3d989db8c342/IJO-52-06-1886-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/8171aaa3a6d0/IJO-52-06-1886-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/7f36f8de3d68/IJO-52-06-1886-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/c8a00d5c8cba/IJO-52-06-1886-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/bf407ea6935f/IJO-52-06-1886-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/5919710/12bab15e4307/IJO-52-06-1886-g05.jpg

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