Sutoo D, Matsukura T, Akiyama K
Institute of Medical Science, University of Tsukuba, Ibaraki-Ken, Japan.
Neurosci Lett. 1987 Dec 4;82(3):297-302. doi: 10.1016/0304-3940(87)90272-2.
The effect of intraventricular administration of calcium on the mean arterial pressure in the conscious rat was investigated. Biphasic changes of blood pressure, fugitive rapid increment during the first 3 min and gradual lengthy decrement during the next 60 min were observed by the administration of CaCl2 (30 mumol/kg). Both these changes were significant as compared with the control level. On the other hand, the biphasic response of blood pressure by CaCl2 was abolished by the administration of calmodulin antagonist, W-7, or catecholamine synthesizing enzyme inhibitor, alpha-methyltyrosine. These results are discussed on the basis of our calcium-calmodulin-dependent biogenic amine-synthesizing mechanism.
研究了脑室内注射钙对清醒大鼠平均动脉压的影响。通过注射氯化钙（30 μmol/kg）观察到血压的双相变化，即最初3分钟内短暂快速升高，随后60分钟内逐渐缓慢下降。与对照水平相比，这两种变化均具有显著性。另一方面，钙调蛋白拮抗剂W-7或儿茶酚胺合成酶抑制剂α-甲基酪氨酸的注射消除了氯化钙引起的血压双相反应。基于我们的钙-钙调蛋白依赖性生物胺合成机制对这些结果进行了讨论。
