Sutoo D, Matsukura T, Akiyama K
Institute of Medical Science, University of Tsukuba, Ibaraki-Ken, Japan.
Eur J Pharmacol. 1988 Oct 11;155(1-2):189-92. doi: 10.1016/0014-2999(88)90422-0.
The mechanism by which exogenous calcium reduces blood pressure was investigated. The verapamil (300 micrograms/kg i.v.)-induced decrease of the mean arterial pressure in the conscious rat was prolonged by 400% by pretreatment with CaCl2 (300 mumol/kg i.v.). This ability of calcium to enhance the effect of verapamil was decreased by i.c.v. injection of EDTA (10 nmol/kg). In light of our previous reports, these results suggest that i.v. calcium reduces blood pressure by a central calcium-calmodulin-dependent mechanism.
研究了外源性钙降低血压的机制。在清醒大鼠中，用氯化钙（300μmol/kg静脉注射）预处理可使维拉帕米（300μg/kg静脉注射）诱导的平均动脉压降低延长400%。脑室注射乙二胺四乙酸（EDTA，10nmol/kg）可降低钙增强维拉帕米作用的能力。根据我们之前的报告，这些结果表明静脉注射钙通过中枢钙-钙调蛋白依赖性机制降低血压。
