• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MORC2，一种新的癌基因，在肝癌中上调，并促进增殖、转移和化疗耐药。

MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance.

机构信息

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Hepatic Disease Institute, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China.

出版信息

Int J Oncol. 2018 Jul;53(1):59-72. doi: 10.3892/ijo.2018.4333. Epub 2018 Mar 27.

DOI:10.3892/ijo.2018.4333
PMID:29620211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5958890/
Abstract

Microrchidia 2 (MORC2) is important in DNA damage repair and lipogenesis, however, the clinical and functional role of MORC2 in liver cancer remains to be fully elucidated. The aim the present study was to clarify the role of MORC2 in liver cancer. Expression profile analysis, immunohistochemical staining, reverse transcription-quantitative polymerase chain reaction analysis and western blot analysis were performed to evaluate the levels of MORC2 in liver cancer patient specimens and cell lines; subsequently the expression of MORC2 was suppressed or increased in liver cancer cells and the effects of MORC2 on the cancerous transformation of liver cancer cells were examined in vitro and in vivo. MORC2 was upregulated in liver cancer tissues, and the upregulation was associated with certain clinicopathologic features of patients with liver cancer. MORC2 knockdown caused marked inhibition of liver cancer cell proliferation and clonogenicity, whereas the overexpression of MORC2 substantially promoted liver cancer cell proliferation. In addition, the knockdown of MORC2 inhibited the migratory and invasive ability of liver cancer cells, whereas increased migration and invasion rates were observed in cells with ectopic expression of MORC2. In a model of nude mice, the overexpression of MORC2 promoted tumorigenicity and markedly enhanced pulmonary metastasis of liver cancer. Furthermore, MORC2 regulated apoptosis and its expression level had an effect on the sensitivity of liver cancer cells to doxorubicin, 5-fluorouracil and cisplatin. Mechanically, MORC2 modulated the mitochondrial apoptotic pathway, possibly in a p53-dependent manner, and its dysregulation also resulted in the abnormal activation of the Hippo pathway. For the first time, to the best of our knowledge, the present study confirmed that MORC2 was a novel oncogene in liver cancer. These results provide useful insight into the mechanism underlying the tumorigenesis and progression of liver cancer, and offers clues into potential novel liver cancer therapies.

摘要

微体相关蛋白 2（MORC2）在 DNA 损伤修复和脂肪生成中发挥重要作用，然而，MORC2 在肝癌中的临床和功能作用仍有待充分阐明。本研究旨在阐明 MORC2 在肝癌中的作用。通过表达谱分析、免疫组织化学染色、逆转录定量聚合酶链反应分析和蛋白质印迹分析来评估肝癌患者标本和细胞系中 MORC2 的水平；随后在肝癌细胞中抑制或增加 MORC2 的表达，并在体外和体内研究 MORC2 对肝癌细胞癌变的影响。MORC2 在肝癌组织中上调，上调与肝癌患者的某些临床病理特征相关。MORC2 敲低显著抑制肝癌细胞的增殖和克隆形成能力，而 MORC2 的过表达则显著促进肝癌细胞的增殖。此外，MORC2 敲低抑制肝癌细胞的迁移和侵袭能力，而在过表达 MORC2 的细胞中观察到迁移和侵袭率增加。在裸鼠模型中，MORC2 的过表达促进了肿瘤发生，并显著增强了肝癌的肺转移。此外，MORC2 调节细胞凋亡，其表达水平影响肝癌细胞对阿霉素、5-氟尿嘧啶和顺铂的敏感性。在机制上，MORC2 调节线粒体凋亡途径，可能依赖于 p53，其失调也导致 Hippo 途径的异常激活。据我们所知，这是首次证实 MORC2 是肝癌的一种新的癌基因。这些结果为肝癌发生和进展的机制提供了有用的见解，并为潜在的肝癌新疗法提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/24c9f8d9caf8/IJO-53-01-0059-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/e5f82c55f1e2/IJO-53-01-0059-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/6a407a39d637/IJO-53-01-0059-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/5d64846e9ca2/IJO-53-01-0059-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/dd69410fa539/IJO-53-01-0059-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/3a92a49b8027/IJO-53-01-0059-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/53680fc853d5/IJO-53-01-0059-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/883090db5e24/IJO-53-01-0059-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/75416f22c69c/IJO-53-01-0059-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/d1fceedbde55/IJO-53-01-0059-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/3421509954b4/IJO-53-01-0059-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/969f3b3710da/IJO-53-01-0059-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/24c9f8d9caf8/IJO-53-01-0059-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/e5f82c55f1e2/IJO-53-01-0059-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/6a407a39d637/IJO-53-01-0059-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/5d64846e9ca2/IJO-53-01-0059-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/dd69410fa539/IJO-53-01-0059-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/3a92a49b8027/IJO-53-01-0059-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/53680fc853d5/IJO-53-01-0059-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/883090db5e24/IJO-53-01-0059-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/75416f22c69c/IJO-53-01-0059-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/d1fceedbde55/IJO-53-01-0059-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/3421509954b4/IJO-53-01-0059-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/969f3b3710da/IJO-53-01-0059-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c3c/5958890/24c9f8d9caf8/IJO-53-01-0059-g11.jpg

相似文献

1
MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance.MORC2，一种新的癌基因，在肝癌中上调，并促进增殖、转移和化疗耐药。
Int J Oncol. 2018 Jul;53(1):59-72. doi: 10.3892/ijo.2018.4333. Epub 2018 Mar 27.
2
MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p.MORC2促进人胆管癌的细胞生长和转移，并受miR-186-5p的负调控。
Aging (Albany NY). 2019 Jun 9;11(11):3639-3649. doi: 10.18632/aging.102003.
3
Aberrant high expression level of MORC2 is a common character in multiple cancers.MORC2 异常高表达水平是多种癌症的共同特征。
Hum Pathol. 2018 Jun;76:58-67. doi: 10.1016/j.humpath.2018.03.011. Epub 2018 Mar 16.
4
Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer.环状 RNA circCDK13 通过调节肝癌中的 JAK/STAT 和 PI3K/AKT 通路抑制细胞增殖、迁移和侵袭。
Int J Oncol. 2018 Jul;53(1):246-256. doi: 10.3892/ijo.2018.4371. Epub 2018 Apr 12.
5
Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells.MORC2 通过表观遗传限制 Hippo 信号通路从而成为肝癌细胞干性的基础。
Cell Death Differ. 2018 Dec;25(12):2086-2100. doi: 10.1038/s41418-018-0095-6. Epub 2018 Mar 19.
6
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.PAK1介导的MORC2磷酸化促进胃癌发生。
Oncotarget. 2015;6(12):9877-86. doi: 10.18632/oncotarget.3185.
7
MORC2 Enhances Tumor Growth by Promoting Angiogenesis and Tumor-Associated Macrophage Recruitment via Wnt/β-Catenin in Lung Cancer.MORC2通过Wnt/β-连环蛋白促进血管生成和肿瘤相关巨噬细胞募集来增强肺癌中的肿瘤生长。
Cell Physiol Biochem. 2018;51(4):1679-1694. doi: 10.1159/000495673. Epub 2018 Nov 30.
8
Long non‑coding RNA FOXD2‑AS1 regulates the tumorigenesis and progression of breast cancer via the S100 calcium binding protein A1/Hippo signaling pathway.长链非编码 RNA FOXD2-AS1 通过 S100 钙结合蛋白 A1/Hippo 信号通路调控乳腺癌的发生发展。
Int J Mol Med. 2020 Oct;46(4):1477-1489. doi: 10.3892/ijmm.2020.4699. Epub 2020 Aug 10.
9
Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells.膜联蛋白 A2 通过激活非小细胞肺癌细胞中的 JNK-p53 通路促进顺铂耐药。
J Exp Clin Cancer Res. 2017 Sep 8;36(1):123. doi: 10.1186/s13046-017-0594-1.
10
DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways.DDIT4 通过 p53 和 MAPK 通路促进胃癌的增殖和肿瘤发生。
Cancer Commun (Lond). 2018 Jul 5;38(1):45. doi: 10.1186/s40880-018-0315-y.

引用本文的文献

1
MORC2 is a phosphorylation-dependent DNA compaction machine.MORC2是一种磷酸化依赖性DNA压缩机器。
Nat Commun. 2025 Jul 1;16(1):5606. doi: 10.1038/s41467-025-60751-z.
2
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in .MORC-1的调控是秀丽隐杆线虫中CSR-1介导的生殖系基因许可机制的关键。
Sci Adv. 2025 Jun 20;11(25):eado4170. doi: 10.1126/sciadv.ado4170.
3
Lactic acid metabolism: gynecological cancer's Achilles' heel.乳酸代谢：妇科癌症的致命弱点。

本文引用的文献

1
HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.HSF1 与 MORC2 结合，通过 PRC2 家族下调胃癌细胞中的 ArgBP2。
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1104-1114. doi: 10.1016/j.bbadis.2018.01.011. Epub 2018 Jan 12.
2
Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1.染色质重塑蛋白MORC2通过PRD结构域介导的与CTNND1的相互作用促进乳腺癌的侵袭和转移。
Oncotarget. 2017 Jun 16;8(58):97941-97954. doi: 10.18632/oncotarget.18556. eCollection 2017 Nov 17.
3
Discov Oncol. 2025 May 2;16(1):657. doi: 10.1007/s12672-025-02364-y.
4
CRISPR/Cas9 system: a novel approach to overcome chemotherapy and radiotherapy resistance in cancer.CRISPR/Cas9系统：一种克服癌症化疗和放疗耐药性的新方法。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):3373-3408. doi: 10.1007/s00210-024-03480-2. Epub 2024 Nov 19.
5
Netrin-1 and UNC5B Cooperate with Integrins to Mediate YAP-Driven Cytostasis.轴突导向因子 Netrin-1 和 UNC5B 与整合素协同作用介导 YAP 驱动的细胞静止。
Cancer Res Commun. 2024 Sep 1;4(9):2374-2383. doi: 10.1158/2767-9764.CRC-24-0101.
6
Emerging roles of the chromatin remodeler MORC2 in cancer metabolism.染色质重塑因子 MORC2 在癌症代谢中的新兴作用。
Med Oncol. 2024 Aug 8;41(9):221. doi: 10.1007/s12032-024-02464-9.
7
Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer.染色质重塑因子 MORC2 在癌症中的作用的新见解。
Biomolecules. 2023 Oct 15;13(10):1527. doi: 10.3390/biom13101527.
8
Identifying Suitable Reference Gene Candidates for Quantification of DNA Damage-Induced Cellular Responses in Human U2OS Cell Culture System.鉴定适用于人 U2OS 细胞培养系统中 DNA 损伤诱导的细胞反应定量的参考基因候选物。
Biomolecules. 2023 Oct 13;13(10):1523. doi: 10.3390/biom13101523.
9
High Expression of MORC2 is Associated with Poor Clinical Outcomes and Immune Infiltrates in Colon Adenocarcinoma.MORC2高表达与结肠腺癌的不良临床预后及免疫浸润相关。
Int J Gen Med. 2023 Oct 11;16:4595-4615. doi: 10.2147/IJGM.S420715. eCollection 2023.
10
Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential.靶向癌症中的Hippo信号通路：新观点与治疗潜力
MedComm (2020). 2023 Oct 3;4(5):e375. doi: 10.1002/mco2.375. eCollection 2023 Oct.
The Hippo signaling pathway provides novel anti-cancer drug targets.
河马信号通路提供了新的抗癌药物靶点。
Oncotarget. 2017 Feb 28;8(9):16084-16098. doi: 10.18632/oncotarget.14306.
4
MORC2 mutations in a cohort of Chinese patients with Charcot-Marie-Tooth disease type 2.一组中国2型夏科-马里-图斯病患者中的MORC2基因突变
Brain. 2016 Oct;139(Pt 10):e56. doi: 10.1093/brain/aww156. Epub 2016 Jun 21.
5
YAP/TAZ at the Roots of Cancer.YAP/TAZ与癌症根源
Cancer Cell. 2016 Jun 13;29(6):783-803. doi: 10.1016/j.ccell.2016.05.005.
6
Severe axonal Charcot-Marie-Tooth disease with proximal weakness caused by de novo mutation in the MORC2 gene.由MORC2基因新发突变引起的伴有近端肌无力的严重轴索性夏科-马里-图斯病
Brain. 2016 Apr;139(Pt 4):e26. doi: 10.1093/brain/awv411. Epub 2016 Feb 11.
7
SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497.SSRP1促进肝细胞癌的恶性发展并受miR-497负调控。
Mol Ther. 2016 May;24(5):903-14. doi: 10.1038/mt.2016.9. Epub 2016 Jan 12.
8
Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells.微小同源框蛋白2（MORC2）通过组蛋白甲基化下调胃癌细胞中的细胞骨架衔接蛋白ArgBP2。
Biochem Biophys Res Commun. 2015 Nov 27;467(4):821-7. doi: 10.1016/j.bbrc.2015.10.059. Epub 2015 Oct 22.
9
Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.大量间质拷贝数中性杂合性缺失作为癌症是一种DNA损伤反应疾病的证据。
BMC Med Genomics. 2015 Jul 25;8:42. doi: 10.1186/s12920-015-0104-2.
10
By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.通过招募HDAC1，MORC2在胃癌中抑制p21 Waf1/Cip1。
Oncotarget. 2015 Jun 30;6(18):16461-70. doi: 10.18632/oncotarget.3889.