Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India.
Med Oncol. 2024 Aug 8;41(9):221. doi: 10.1007/s12032-024-02464-9.
Cancer is characterized by metabolic reprogramming in cancer cells, which is crucial for tumorigenesis. The highly deregulated chromatin remodeler MORC2 contributes to cell proliferation, invasion, migration, DNA repair, and chemoresistance. MORC2 also plays a key role in metabolic reprogramming, including lipogenesis, glucose, and glutamine metabolism. A recent study showed that MORC2-regulated glucose metabolism affects the expression of E-cadherin, a crucial protein in the epithelial-to-mesenchymal transition. This review discusses recent developments in MORC2 regulated cancer cell metabolism and its role in cancer progression.
癌症的特征是癌细胞中的代谢重编程，这对于肿瘤发生至关重要。高度失调的染色质重塑因子 MORC2 促进细胞增殖、侵袭、迁移、DNA 修复和化疗耐药性。MORC2 还在代谢重编程中发挥关键作用，包括脂肪生成、葡萄糖和谷氨酰胺代谢。最近的一项研究表明，MORC2 调节的葡萄糖代谢会影响上皮-间充质转化中关键蛋白 E-钙黏蛋白的表达。本综述讨论了 MORC2 调节的癌细胞代谢及其在癌症进展中的作用的最新进展。
