Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province , Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu , 610041 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
ACS Comb Sci. 2018 May 14;20(5):292-297. doi: 10.1021/acscombsci.8b00005. Epub 2018 Apr 11.
Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1 H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.
在酸性条件下，通过相应的丙二烯中间体，γ-炔基酮一锅法构建取代呋喃。该方法也适用于一系列 Ugi 反应产物，用于合成 6-甲基吡嗪-2(1H)-酮衍生物。该方法为这些化学支架的组合应用提供了显著的优势。
