Brunner H R, Biollaz J, Waeber B, Nussberger J
Département de médecine, Centre hospitalier universitaire vaudois, Lausanne.
Schweiz Med Wochenschr. 1987 Dec 5;117(49):1937-40.
Myocardial cells of mammals release a peptide with diuretic, natriuretic and vasodilating properties into the circulation. This peptide, called atrial natriuretic factor, is also involved in the regulation of plasma volume and, in addition, is instrumental in suppressing the activity of the renin-angiotensin-aldosterone system. The renal effects of the atrial natriuretic factor become less pronounced when systemic blood pressure is lowered. The auricular natriuretic factor seems to play an important role in cardiovascular regulation due to both its renal and extrarenal actions.
哺乳动物的心肌细胞会释放一种具有利尿、利钠和血管舒张特性的肽进入血液循环。这种肽被称为心房利钠因子，它也参与血浆容量的调节，此外，还有助于抑制肾素 - 血管紧张素 - 醛固酮系统的活性。当全身血压降低时，心房利钠因子的肾脏效应会变得不那么明显。由于其肾脏和肾外作用，心房利钠因子似乎在心血管调节中发挥重要作用。
