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埃塞俄比亚西北部贡德尔大学医院接受抗精神病药物治疗的精神病患者中未诊断出的糖尿病及其相关因素

Undiagnosed Diabetes Mellitus and Associated Factors among Psychiatric Patients Receiving Antipsychotic Drugs at The University of Gondar Hospital, Northwest Ethiopia.

作者信息

Asmelash Daniel, Getnet Wondale, Biadgo Belete, Ambachew Sintayehu, Melak Tadele, Melese Lemmesa, Damite Shiwaneh, Baynes Habtamu Wondifraw, Abebe Molla

机构信息

Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

University of Gondar Hospital Laboratory, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

Ethiop J Health Sci. 2018 Jan;28(1):3-10. doi: 10.4314/ejhs.v28i1.2.

Abstract

BACKGROUND

Undiagnosed diabetes mellitus cases are at higher risk for diabetic related complications. In low-income African countries, patients with undiagnosed diabetes mellitus account for 75% of diabetes cases. Psychiatric disorders have a greater impact on the global burden of diseases and disability associated with chronic diseases like diabetes mellitus and cardiovascular diseases.

METHODS

Institution based cross-sectional study was conducted at the University of Gondar Hospital from February to April 2016. A total of 205 psychiatric patients aged above 15 years that were taking antipsychotic were included by the simple random sampling method. Fasting blood glucose, triglycerides and cholesterol level were determined from venous blood samples to evaluate diabetes mellitus based on WHO criteria.

RESULTS

Among 205 psychiatric patients taking antipsychotics, 15(7.3%) had undiagnosed diabetes mellitus. Duration of antipsychotic treatment and sex had a statistically significant association with the prevalence of undiagnosed diabetes mellitus. As the duration of antipsychotic drug treatment increased by one year, the risk of having a diabetes mellitus increase by 1.47 times (AOR: 1.47 CI: 1.021-2.125).

CONCLUSION

The prevalence of undiagnosed diabetes mellitus among psychiatry patients taking antipsychotics was higher than the estimated diabetes national prevalence of Ethiopia. Screening of diabetes mellitus in particular, patients having a longer duration of antipsychotic treatment is mandatory to bring more undiagnosed cases for medical attention.

摘要

背景

未确诊的糖尿病患者发生糖尿病相关并发症的风险更高。在低收入非洲国家,未确诊的糖尿病患者占糖尿病病例的75%。精神障碍对与糖尿病和心血管疾病等慢性病相关的全球疾病负担和残疾影响更大。

方法

2016年2月至4月在贡德尔大学医院开展了一项基于机构的横断面研究。通过简单随机抽样方法纳入了总共205名年龄在15岁以上正在服用抗精神病药物的精神科患者。从静脉血样本中测定空腹血糖、甘油三酯和胆固醇水平,以根据世界卫生组织标准评估糖尿病。

结果

在205名服用抗精神病药物的精神科患者中,15名(7.3%)患有未确诊的糖尿病。抗精神病药物治疗时间和性别与未确诊糖尿病的患病率存在统计学显著关联。随着抗精神病药物治疗时间每增加一年,患糖尿病的风险增加1.47倍(调整后比值比:1.47;可信区间:1.021 - 2.125)。

结论

服用抗精神病药物的精神科患者中未确诊糖尿病的患病率高于埃塞俄比亚全国估计的糖尿病患病率。特别是对服用抗精神病药物时间较长的患者进行糖尿病筛查,对于发现更多未确诊病例以便就医至关重要。

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