继发孔型房间隔缺损的自然闭合
Spontaneous Closure of a Secundum Atrial Septal Defect.
作者信息
Wang Stephen Y, Welch Terrence D, Elfenbein Aryé, Kaplan Aaron V
机构信息
aGEISEL SCHOOL OF MEDICINE AT DARTMOUTH, HANOVER, NEW HAMPSHIRE.
bYALE UNIVERSITY SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT.
出版信息
Methodist Debakey Cardiovasc J. 2018 Jan-Mar;14(1):60-62. doi: 10.14797/mdcj-14-1-60.
Abstract
Spontaneous closure of an atrial septal defect (ASD) is well described in pediatric cardiology but may be less familiar to adult internists and cardiologists. We report a moderately sized 6-mm ASD that closed spontaneously without intervention. A literature review found that a smaller defect size and an early age of diagnosis are the most important predictors of closure. Possible mechanisms of a spontaneous ASD closure include adaptive endothelial migration, limited myocardial proliferation, and fibroblast migration with extracellular matrix deposition.
摘要
房间隔缺损（ASD）的自然闭合在小儿心脏病学中有详细描述，但成年内科医生和心脏病专家可能对此不太熟悉。我们报告了一例直径6毫米的中等大小ASD，未经干预而自然闭合。文献综述发现，较小的缺损尺寸和较早的诊断年龄是闭合的最重要预测因素。ASD自然闭合的可能机制包括适应性内皮迁移、有限的心肌增殖以及成纤维细胞迁移和细胞外基质沉积。
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