Rosenberg Jillian, Huang Jun
Committee on Cancer Biology, The University of Chicago, IL 60637, USA.
Institute for Molecular Engineering, The University of Chicago, IL 60637, USA.
Curr Opin Chem Eng. 2018 Mar;19:9-20. doi: 10.1016/j.coche.2017.11.006. Epub 2017 Dec 14.
CD8 T cells and NK cells are both cytotoxic effector cells of the immune system, but the recognition, specificity, sensitivity, and memory mechanisms are drastically different. While many of these topics have been extensively studied in CD8 T cells, very little is known about NK cells. Current cancer immunotherapies mainly focus on CD8 T cells, but have many issues of toxicity and efficacy. Given the heterogeneous nature of cancer, personalized cancer immunotherapy that integrates the power of both CD8 T cells in adaptive immunity and NK cells in innate immunity might be the future direction, along with precision targeting and effective delivery of tumor-specific, memory CD8 T cells and NK cells.
CD8 T细胞和自然杀伤（NK）细胞都是免疫系统的细胞毒性效应细胞，但它们的识别、特异性、敏感性和记忆机制却大不相同。虽然其中许多主题已在CD8 T细胞中得到广泛研究，但关于NK细胞的了解却非常少。目前的癌症免疫疗法主要集中在CD8 T细胞上，但存在许多毒性和疗效问题。鉴于癌症的异质性，整合适应性免疫中的CD8 T细胞和先天性免疫中的NK细胞的个性化癌症免疫疗法可能是未来的方向，同时还需要精准靶向和有效递送肿瘤特异性记忆CD8 T细胞和NK细胞。
