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2017年捷克共和国H5N8/H5N5高致病性禽流感疫情期间，微进化和独立入侵是塑造H5血凝素多样性的主要力量。

Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017.

作者信息

Nagy Alexander, Dán Ádám, Černíková Lenka, Vitásková Eliška, Křivda Vlastimil, Horníčková Jitka, Masopust Roman, Sedlák Kamil

机构信息

State Veterinary Institute Prague, Sídlištní 136/24, 16503, Prague, Czech Republic.

National Food Chain Safety Office, Veterinary Diagnostic Institute, Tábornok utca 2, Budapest, 1143, Hungary.

出版信息

Arch Virol. 2018 Aug;163(8):2219-2224. doi: 10.1007/s00705-018-3833-7. Epub 2018 Apr 5.

DOI:10.1007/s00705-018-3833-7
PMID:29623433
Abstract

Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.

摘要

在此，我们对2017年捷克共和国疫情期间检测到的H5N8/H5N5高致病性禽流感（HPAI）病毒株进行了全面分析。对99%疫情发生地的H5血凝素（HA）进行网络分析表明，捷克H5N8/H5N5病毒的多样性受两种基本力量影响：局部微进化和独立入侵。中心节点H5 HA序列的地理分布揭示了三个生态区域，这三个生态区域显然在当地H5N8/HPAI变异株在全国的起源和进一步传播中发挥了重要作用。同时还对观察到的多样性模式给出了一个合理的解释。

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