Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sci China Life Sci. 2018 Apr;61(4):373-379. doi: 10.1007/s11427-017-9257-1. Epub 2018 Mar 29.
Obesity, as a chronic condition, has been a serious public health issue over the last decades both in the affluent Western world and developing countries. As reported, the risk of several serious diseases increases with weight gain, including type 2 diabetes, coronary heart disease, cancer, and respiratory diseases. In addition to lifestyle modifications, pharmacotherapy has become an important strategy to control weight gain. However, most of the anti-obesity drugs often show poor outcome for weight-loss and cause severe adverse effects. This review surveys recent advances in nanomedicine as an emerging strategy for obesity treatment with an emphasis on the enhanced therapeutic efficiency and minimized side effects. The insights for future development are also discussed.
肥胖作为一种慢性疾病，在过去几十年中，无论是在富裕的西方国家还是发展中国家，都是一个严重的公共卫生问题。据报道，体重增加会增加患多种严重疾病的风险，包括 2 型糖尿病、冠心病、癌症和呼吸系统疾病。除了生活方式的改变，药物治疗已成为控制体重增加的重要策略。然而，大多数减肥药往往在减肥方面效果不佳，并导致严重的不良反应。本综述调查了纳米医学作为肥胖治疗的新兴策略的最新进展，重点是提高治疗效果和最小化副作用。还讨论了未来发展的见解。
