College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Pharm Res. 2021 Aug;38(8):1327-1334. doi: 10.1007/s11095-021-03081-1. Epub 2021 Aug 16.
Obesity expands as a global climbing epidemic that is often correlated to cardiovascular diseases and endocrine disorders. Converting white adipocytes to brown adipocytes for enhanced energy expenditure has recently emerged as a promising anti-obesity treatment. However, the conventional approaches to apply browning agents systematically suffer from off-target effects, multiple dosage requirements, and poor patient compliance. To date, various delivery strategies have been reported to deliver browning agents for obesity treatment in a safer and more controllable manner. This review will discuss the latest designs in browning agent delivery systems with a focus on nanomedicines and transdermal patches.
肥胖症是一种全球性的流行疾病，常与心血管疾病和内分泌紊乱有关。将白色脂肪细胞转化为棕色脂肪细胞以增加能量消耗，最近已成为一种很有前途的抗肥胖治疗方法。然而，传统的应用褐色脂肪细胞诱导剂的方法存在脱靶效应、多种剂量需求和患者顺应性差等问题。迄今为止，已有多种传递策略被报道用于以更安全、更可控的方式传递褐色脂肪细胞诱导剂来治疗肥胖症。本文将重点讨论纳米医学和透皮贴剂等新型褐色脂肪细胞诱导剂传递系统的最新设计。
