Department of Orthopaedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, China.
Biol Trace Elem Res. 2018 Dec;186(2):379-383. doi: 10.1007/s12011-018-1332-z. Epub 2018 Apr 5.
Sarcopenia has a high incidence among the elderly, with significant negative effects on the quality of life. The pathogenesis of sarcopenia is complex, and many factors are involved in its development and progression. Sarcopenia might be associated with iron accumulation given that (1) age-related iron accumulation was found in the skeletal muscle, (2) excess iron could cause skeletal muscle damage or atrophy, and (3) patients with sarcopenia showed higher levels of serum ferritin. Understanding the etiology and pathogenesis of sarcopenia would help to develop new treatment and preventive methods, thereby improving the quality of life of the elderly patients.
肌少症在老年人中发病率较高，对生活质量有显著的负面影响。肌少症的发病机制复杂，许多因素参与其发生发展。肌少症可能与铁蓄积有关，因为（1）在骨骼肌中发现了与年龄相关的铁蓄积，（2）过量的铁会导致骨骼肌损伤或萎缩，以及（3）肌少症患者的血清铁蛋白水平更高。了解肌少症的病因和发病机制有助于开发新的治疗和预防方法，从而提高老年患者的生活质量。
