Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Department of Gerontology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, Jiangsu, China.
Sci Rep. 2024 May 8;14(1):10554. doi: 10.1038/s41598-024-61429-0.
Sarcopenia greatly reduces the quality of life of the elderly, and iron metabolism plays an important role in muscle loss. This study aimed to investigate the association between iron status and sarcopenia. A total of 286 adult patients hospitalized between 2019 and 2021 were included in this study, of which 117 were diagnosed with sarcopenia. Serum iron, total iron binding capacity (TIBC), transferrin, and transferrin saturation levels were compared between groups with and without sarcopenia and were included in the logistic analyses, with significant variables further included in the logistic regression model for the prediction of sarcopenia. Serum iron, TIBC, and transferrin levels decreased significantly in the sarcopenia group (p < 0.05), and were negatively associated with handgrip strength, relative skeletal muscle index, and multiple test performances (p < 0.05). Multivariate logistic analysis showed that sex, age, body mass index (BMI), and serum iron level were independent risk factors for sarcopenia. In the final logistic regression model, male sex (odds ratio [OR] 3.65, 95% confidence interval [CI] 1.67-7.98), age > 65 years (OR 5.40, 95% CI 2.25-12.95), BMI < 24 kg/m (OR 0.17, 95% CI 0.08-0.36), and serum iron < 10.95 μmol/L (OR 0.39, 95% CI 0.16-0.93) were included. Our study supported the impact of iron metabolism on muscle strength and performance.
肌肉减少症极大地降低了老年人的生活质量，而铁代谢在肌肉减少中起着重要作用。本研究旨在探讨铁状态与肌肉减少症之间的关系。本研究共纳入 2019 年至 2021 年期间住院的 286 名成年患者，其中 117 例被诊断为肌肉减少症。比较了有无肌肉减少症患者之间的血清铁、总铁结合力（TIBC）、转铁蛋白和转铁蛋白饱和度水平，并将有意义的变量纳入逻辑分析，将显著变量进一步纳入肌肉减少症的逻辑回归模型预测。肌肉减少症组的血清铁、TIBC 和转铁蛋白水平显著降低（p<0.05），且与握力、相对骨骼肌指数和多项测试表现呈负相关（p<0.05）。多变量逻辑分析显示，性别、年龄、体重指数（BMI）和血清铁水平是肌肉减少症的独立危险因素。在最终的逻辑回归模型中，男性（比值比[OR]3.65，95%置信区间[CI]1.67-7.98）、年龄>65 岁（OR5.40，95%CI2.25-12.95）、BMI<24 kg/m（OR0.17，95%CI0.08-0.36）和血清铁<10.95 μmol/L（OR0.39，95%CI0.16-0.93）。我们的研究支持铁代谢对肌肉力量和表现的影响。
